Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies

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@article{60557ad57923447db86a8b851fb62f88,
title = "Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies",
abstract = "Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (In-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P< 0.0001] and insulin (-0.020 In-pmo/L (95% CI: -0.024, -0.017), P< 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P= 0.03) with glucose, and rs11558471 in SLC30A8and rs3740393 near CNNM2showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. J. Nutr. 143: 345-353, 2013.",
author = "Adela Hruby and Ngwa, {Julius S.} and Frida Renstr{\"o}m and Wojczynski, {Mary K.} and Andrea Ganna and Goran Hallmans and Houston, {Denise K.} and Jacques, {Paul F.} and Stavroula Kanoni and Terho Lehtimaki and Lemaitre, {Rozenn N.} and Ani Manichaikul and North, {Kari E.} and Ioanna Ntalla and Emily Sonestedt and Toshiko Tanaka and {van Rooij}, {Frank J. A.} and Stefania Bandinelli and Luc Djousse and Efi. Grigoriou and Ingegerd Johansson and Lohman, {Kurt K.} and Pankow, {James S.} and Raitakari, {Olli T.} and Ulf Riserus and Mary Yannakoulia and Zillikens, {M. Carola} and Neelam Hassanali and Yongmei Liu and Dariush Mozaffarian and Constantina Papoutsakis and Ann-Christine Syvanen and Uitterlinden, {Andre G.} and Jorma Viikari and Groves, {Christopher J.} and Albert Hofman and Lars Lind and McCarthy, {Mark I.} and Vera Mikkila and Kenneth Mukamal and Franco, {Oscar H.} and Borecki, {Ingrid B.} and Cupples, {L. Adrienne} and Dedoussis, {George V.} and Luigi Ferrucci and Hu, {Frank B.} and Erik Ingelsson and Mika Kahonen and Kao, {W. H. Linda} and Kritchevsky, {Stephen B.} and Marju Orho-Melander and Inga Prokopenko and Rotter, {Jerome I.} and Siscovick, {David S.} and Witteman, {Jacqueline C. M.} and Paul Franks and Meigs, {James B.} and McKeown, {Nicola M.} and Nettleton, {Jennifer A.}",
year = "2013",
doi = "10.3945/jn.112.172049",
language = "English",
volume = "143",
pages = "345--353",
journal = "Journal of Nutrition",
issn = "1541-6100",
publisher = "Oxford University Press",
number = "3",

}