Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies

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Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies. / Hruby, Adela; Ngwa, Julius S.; Renström, Frida; Wojczynski, Mary K.; Ganna, Andrea; Hallmans, Goran; Houston, Denise K.; Jacques, Paul F.; Kanoni, Stavroula; Lehtimaki, Terho; Lemaitre, Rozenn N.; Manichaikul, Ani; North, Kari E.; Ntalla, Ioanna; Sonestedt, Emily; Tanaka, Toshiko; van Rooij, Frank J. A.; Bandinelli, Stefania; Djousse, Luc; Grigoriou, Efi.; Johansson, Ingegerd; Lohman, Kurt K.; Pankow, James S.; Raitakari, Olli T.; Riserus, Ulf; Yannakoulia, Mary; Zillikens, M. Carola; Hassanali, Neelam; Liu, Yongmei; Mozaffarian, Dariush; Papoutsakis, Constantina; Syvanen, Ann-Christine; Uitterlinden, Andre G.; Viikari, Jorma; Groves, Christopher J.; Hofman, Albert; Lind, Lars; McCarthy, Mark I.; Mikkila, Vera; Mukamal, Kenneth; Franco, Oscar H.; Borecki, Ingrid B.; Cupples, L. Adrienne; Dedoussis, George V.; Ferrucci, Luigi; Hu, Frank B.; Ingelsson, Erik; Kahonen, Mika; Kao, W. H. Linda; Kritchevsky, Stephen B.; Orho-Melander, Marju; Prokopenko, Inga; Rotter, Jerome I.; Siscovick, David S.; Witteman, Jacqueline C. M.; Franks, Paul; Meigs, James B.; McKeown, Nicola M.; Nettleton, Jennifer A.

In: Journal of Nutrition, Vol. 143, No. 3, 2013, p. 345-353.

Research output: Contribution to journalArticle

Harvard

Hruby, A, Ngwa, JS, Renström, F, Wojczynski, MK, Ganna, A, Hallmans, G, Houston, DK, Jacques, PF, Kanoni, S, Lehtimaki, T, Lemaitre, RN, Manichaikul, A, North, KE, Ntalla, I, Sonestedt, E, Tanaka, T, van Rooij, FJA, Bandinelli, S, Djousse, L, Grigoriou, E, Johansson, I, Lohman, KK, Pankow, JS, Raitakari, OT, Riserus, U, Yannakoulia, M, Zillikens, MC, Hassanali, N, Liu, Y, Mozaffarian, D, Papoutsakis, C, Syvanen, A-C, Uitterlinden, AG, Viikari, J, Groves, CJ, Hofman, A, Lind, L, McCarthy, MI, Mikkila, V, Mukamal, K, Franco, OH, Borecki, IB, Cupples, LA, Dedoussis, GV, Ferrucci, L, Hu, FB, Ingelsson, E, Kahonen, M, Kao, WHL, Kritchevsky, SB, Orho-Melander, M, Prokopenko, I, Rotter, JI, Siscovick, DS, Witteman, JCM, Franks, P, Meigs, JB, McKeown, NM & Nettleton, JA 2013, 'Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies', Journal of Nutrition, vol. 143, no. 3, pp. 345-353. https://doi.org/10.3945/jn.112.172049

APA

Hruby, A., Ngwa, J. S., Renström, F., Wojczynski, M. K., Ganna, A., Hallmans, G., Houston, D. K., Jacques, P. F., Kanoni, S., Lehtimaki, T., Lemaitre, R. N., Manichaikul, A., North, K. E., Ntalla, I., Sonestedt, E., Tanaka, T., van Rooij, F. J. A., Bandinelli, S., Djousse, L., ... Nettleton, J. A. (2013). Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies. Journal of Nutrition, 143(3), 345-353. https://doi.org/10.3945/jn.112.172049

CBE

Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimaki T, Lemaitre RN, Manichaikul A, North KE, Ntalla I, Sonestedt E, Tanaka T, van Rooij FJA, Bandinelli S, Djousse L, Grigoriou E, Johansson I, Lohman KK, Pankow JS, Raitakari OT, Riserus U, Yannakoulia M, Zillikens MC, Hassanali N, Liu Y, Mozaffarian D, Papoutsakis C, Syvanen A-C, Uitterlinden AG, Viikari J, Groves CJ, Hofman A, Lind L, McCarthy MI, Mikkila V, Mukamal K, Franco OH, Borecki IB, Cupples LA, Dedoussis GV, Ferrucci L, Hu FB, Ingelsson E, Kahonen M, Kao WHL, Kritchevsky SB, Orho-Melander M, Prokopenko I, Rotter JI, Siscovick DS, Witteman JCM, Franks P, Meigs JB, McKeown NM, Nettleton JA. 2013. Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies. Journal of Nutrition. 143(3):345-353. https://doi.org/10.3945/jn.112.172049

MLA

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Author

Hruby, Adela ; Ngwa, Julius S. ; Renström, Frida ; Wojczynski, Mary K. ; Ganna, Andrea ; Hallmans, Goran ; Houston, Denise K. ; Jacques, Paul F. ; Kanoni, Stavroula ; Lehtimaki, Terho ; Lemaitre, Rozenn N. ; Manichaikul, Ani ; North, Kari E. ; Ntalla, Ioanna ; Sonestedt, Emily ; Tanaka, Toshiko ; van Rooij, Frank J. A. ; Bandinelli, Stefania ; Djousse, Luc ; Grigoriou, Efi. ; Johansson, Ingegerd ; Lohman, Kurt K. ; Pankow, James S. ; Raitakari, Olli T. ; Riserus, Ulf ; Yannakoulia, Mary ; Zillikens, M. Carola ; Hassanali, Neelam ; Liu, Yongmei ; Mozaffarian, Dariush ; Papoutsakis, Constantina ; Syvanen, Ann-Christine ; Uitterlinden, Andre G. ; Viikari, Jorma ; Groves, Christopher J. ; Hofman, Albert ; Lind, Lars ; McCarthy, Mark I. ; Mikkila, Vera ; Mukamal, Kenneth ; Franco, Oscar H. ; Borecki, Ingrid B. ; Cupples, L. Adrienne ; Dedoussis, George V. ; Ferrucci, Luigi ; Hu, Frank B. ; Ingelsson, Erik ; Kahonen, Mika ; Kao, W. H. Linda ; Kritchevsky, Stephen B. ; Orho-Melander, Marju ; Prokopenko, Inga ; Rotter, Jerome I. ; Siscovick, David S. ; Witteman, Jacqueline C. M. ; Franks, Paul ; Meigs, James B. ; McKeown, Nicola M. ; Nettleton, Jennifer A. / Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies. In: Journal of Nutrition. 2013 ; Vol. 143, No. 3. pp. 345-353.

RIS

TY - JOUR

T1 - Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies

AU - Hruby, Adela

AU - Ngwa, Julius S.

AU - Renström, Frida

AU - Wojczynski, Mary K.

AU - Ganna, Andrea

AU - Hallmans, Goran

AU - Houston, Denise K.

AU - Jacques, Paul F.

AU - Kanoni, Stavroula

AU - Lehtimaki, Terho

AU - Lemaitre, Rozenn N.

AU - Manichaikul, Ani

AU - North, Kari E.

AU - Ntalla, Ioanna

AU - Sonestedt, Emily

AU - Tanaka, Toshiko

AU - van Rooij, Frank J. A.

AU - Bandinelli, Stefania

AU - Djousse, Luc

AU - Grigoriou, Efi.

AU - Johansson, Ingegerd

AU - Lohman, Kurt K.

AU - Pankow, James S.

AU - Raitakari, Olli T.

AU - Riserus, Ulf

AU - Yannakoulia, Mary

AU - Zillikens, M. Carola

AU - Hassanali, Neelam

AU - Liu, Yongmei

AU - Mozaffarian, Dariush

AU - Papoutsakis, Constantina

AU - Syvanen, Ann-Christine

AU - Uitterlinden, Andre G.

AU - Viikari, Jorma

AU - Groves, Christopher J.

AU - Hofman, Albert

AU - Lind, Lars

AU - McCarthy, Mark I.

AU - Mikkila, Vera

AU - Mukamal, Kenneth

AU - Franco, Oscar H.

AU - Borecki, Ingrid B.

AU - Cupples, L. Adrienne

AU - Dedoussis, George V.

AU - Ferrucci, Luigi

AU - Hu, Frank B.

AU - Ingelsson, Erik

AU - Kahonen, Mika

AU - Kao, W. H. Linda

AU - Kritchevsky, Stephen B.

AU - Orho-Melander, Marju

AU - Prokopenko, Inga

AU - Rotter, Jerome I.

AU - Siscovick, David S.

AU - Witteman, Jacqueline C. M.

AU - Franks, Paul

AU - Meigs, James B.

AU - McKeown, Nicola M.

AU - Nettleton, Jennifer A.

PY - 2013

Y1 - 2013

N2 - Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (In-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P< 0.0001] and insulin (-0.020 In-pmo/L (95% CI: -0.024, -0.017), P< 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P= 0.03) with glucose, and rs11558471 in SLC30A8and rs3740393 near CNNM2showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. J. Nutr. 143: 345-353, 2013.

AB - Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (In-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P< 0.0001] and insulin (-0.020 In-pmo/L (95% CI: -0.024, -0.017), P< 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P= 0.03) with glucose, and rs11558471 in SLC30A8and rs3740393 near CNNM2showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. J. Nutr. 143: 345-353, 2013.

U2 - 10.3945/jn.112.172049

DO - 10.3945/jn.112.172049

M3 - Article

VL - 143

SP - 345

EP - 353

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 1541-6100

IS - 3

ER -