Hög tid att pröva hypotermi i behandlingen av slaganfall

Research output: Contribution to journalArticle

Abstract

There is a revived clinical interest in hypothermia as a neuroprotective intervention in brain ischemia. This originates from the experimental finding that hypothermia of only 3 degrees C-4 degrees C below normal body temperature completely abolishes neuronal damage from an ischemic insult that is lethal in normothermia. The idea that hypothermia protects cells from ischemic damage mainly by lowering metabolic rate is challenged. We propose that detrimental protein-lipid interactions in brain cells, that are activated during and following brain ischemia and that mediate adverse cellular signaling and lead to cell death, are blunted or prevented by mild hypothermia.

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Subject classification (UKÄ) – MANDATORY

  • Neurology
Translated title of the contribution[High time to test hypothermia in the treatment of stroke]
Original languageSwedish
Pages (from-to)2172-2175
JournalLäkartidningen
Volume98
Issue number18
Publication statusPublished - 2001
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000)