Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Research output: Contribution to journalArticle

Abstract

A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

Details

Authors
  • Elin Kindberg
  • Britt Akerlind
  • Christina Johnsen
  • Jenny Dahl Knudsen
  • Ole Heltberg
  • Göran Larson
  • Blenda Böttiger
  • Lennart Svensson
External organisations
  • Danish Serum Institute, Copenhagen
Research areas and keywords

Keywords

  • Caliciviridae Infections/epidemiology, Codon, Nonsense, Denmark, Disease Outbreaks, Fucosyltransferases/genetics, Genotype, Humans, Immunity, Innate/genetics
Original languageEnglish
Pages (from-to)2720-2
Number of pages3
JournalJournal of Clinical Microbiology
Volume45
Issue number8
Publication statusPublished - 2007 Aug
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes