Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Research output: Contribution to journalArticle

Standard

Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark. / Kindberg, Elin; Akerlind, Britt; Johnsen, Christina; Knudsen, Jenny Dahl; Heltberg, Ole; Larson, Göran; Böttiger, Blenda; Svensson, Lennart.

In: Journal of Clinical Microbiology, Vol. 45, No. 8, 08.2007, p. 2720-2.

Research output: Contribution to journalArticle

Harvard

Kindberg, E, Akerlind, B, Johnsen, C, Knudsen, JD, Heltberg, O, Larson, G, Böttiger, B & Svensson, L 2007, 'Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark', Journal of Clinical Microbiology, vol. 45, no. 8, pp. 2720-2. https://doi.org/10.1128/JCM.00162-07

APA

Kindberg, E., Akerlind, B., Johnsen, C., Knudsen, J. D., Heltberg, O., Larson, G., Böttiger, B., & Svensson, L. (2007). Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark. Journal of Clinical Microbiology, 45(8), 2720-2. https://doi.org/10.1128/JCM.00162-07

CBE

MLA

Vancouver

Kindberg E, Akerlind B, Johnsen C, Knudsen JD, Heltberg O, Larson G et al. Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark. Journal of Clinical Microbiology. 2007 Aug;45(8):2720-2. https://doi.org/10.1128/JCM.00162-07

Author

Kindberg, Elin ; Akerlind, Britt ; Johnsen, Christina ; Knudsen, Jenny Dahl ; Heltberg, Ole ; Larson, Göran ; Böttiger, Blenda ; Svensson, Lennart. / Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark. In: Journal of Clinical Microbiology. 2007 ; Vol. 45, No. 8. pp. 2720-2.

RIS

TY - JOUR

T1 - Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

AU - Kindberg, Elin

AU - Akerlind, Britt

AU - Johnsen, Christina

AU - Knudsen, Jenny Dahl

AU - Heltberg, Ole

AU - Larson, Göran

AU - Böttiger, Blenda

AU - Svensson, Lennart

PY - 2007/8

Y1 - 2007/8

N2 - A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

AB - A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

KW - Caliciviridae Infections/epidemiology

KW - Codon, Nonsense

KW - Denmark

KW - Disease Outbreaks

KW - Fucosyltransferases/genetics

KW - Genotype

KW - Humans

KW - Immunity, Innate/genetics

U2 - 10.1128/JCM.00162-07

DO - 10.1128/JCM.00162-07

M3 - Article

C2 - 17537929

VL - 45

SP - 2720

EP - 2722

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 1098-660X

IS - 8

ER -