Host–pathogen interactions of nontypeable Haemophilus influenzae: from commensal to pathogen

Research output: Contribution to journalReview article

Abstract

Nontypeable Haemophilus influenzae (NTHi) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against H. influenzae serotype b in the 1990s, the burden of H. influenzae-related infections has been increasingly dominated by NTHi. Understanding the ability of NTHi to cause infection is currently an expanding area of study. NTHi is able to exert differential binding to the host tissue through the use of a broad range of adhesins. NTHi survival in the host is multifaceted, that is, using virulence factors involved in complement resistance, biofilm, modified immunoglobulin responses, and, finally, formation and utilization of host proteins as a secondary strategy of increasing the adhesive ability.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area

Keywords

  • adhesion, biofilm formation, extracellular matrix, Haemophilus, intracellular, serum resistance
Original languageEnglish
Pages (from-to)3840-3853
Number of pages14
JournalFEBS Letters
Volume590
Issue number21
Publication statusPublished - 2016 Nov 1
Publication categoryResearch
Peer-reviewedYes