How to build a lung: latest advances and emerging themes in lung bioengineering

Research output: Contribution to journalArticle

Abstract

Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation. Recently, there have been significant efforts to scale-up cell culture methods to generate adequate cell numbers for human-scale bioengineering approaches. Concomitantly, there have been exciting efforts in designing bioreactors that allow for appropriate cell seeding and development of functional lung tissue over time. This review aims to present the current state-of-the-art progress for each of these areas and to discuss promising new ideas within the field of lung bioengineering.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Helmholtz Zentrum München
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Biotechnology
  • Respiratory Medicine and Allergy
Original languageEnglish
Article number1601355
Pages (from-to)1-19
JournalEuropean Respiratory Journal
Volume52
Publication statusPublished - 2018 Jul
Publication categoryResearch
Peer-reviewedYes