Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies

Research output: Contribution to journalArticle

Abstract

In this article, Roybon and colleagues developed a protocol to efficiently and rapidly generate hippocampus neurons from human induced pluripotent stem cells, which they used to model Alzheimer disease and develop a gene therapy approach to modulate the expression of genes involved in synaptic transmission.

Details

Authors
  • Marita Grønning Hansen
  • Tessa de Vries
  • Anna Sancho-Balsells
  • Anna Collin
  • Ana Rita Vaz
  • Silvia Bagnoli
  • Benedetta Nacmias
  • Claire Rampon
  • Sandro Sorbi
  • Dora Brites
Organisations
External organisations
  • University of Lisbon
  • University of Florence
  • IRCCS Don Gnocchi Foundation
  • Université Paul Sabatier
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
  • Cell and Molecular Biology

Keywords

  • Alzheimer disease, hippocampus, iPSC, NeuroD1, protein aggregation, proteomics, spheroids, transcriptomics, viral-mediated gene therapy
Original languageEnglish
Pages (from-to)256-273
Number of pages18
JournalStem Cell Reports
Volume15
Issue number1
Publication statusPublished - 2020
Publication categoryResearch
Peer-reviewedYes