Human papilloma virus in skin, mouth and uterine cervix in female renal transplant recipients with or without a history of cutaneous squamous cell carcinoma

Research output: Contribution to journalArticle

Abstract

Some human papilloma viruses are thought to be associated with skin cancer. In this pilot study, 21 female renal transplant carriers, 10 with a history of skin squamous cell carcinoma and 11 without, together with 9 age-matched healthy women were investigated for human papilloma virus DNA in sun-exposed (forehead) and less sun-exposed (buttock) skin, mouth and uterine cervix. Paraffin-embedded tumours from 9 of the patients with a history of squamous cell carcinoma were analysed. Healthy skin from both the healthy and the immunosuppressed individuals harboured a wide variety of papilloma viruses. In the healthy individuals, samples from less sun-exposed skin showed a lower prevalence of human papilloma virus DNA than corresponding samples from the immunosuppressed patients (4/9 and 7/9, respectively). Among the immunosuppressed patients, human papillomavirus DNA was found as frequently in buttock samples (17/21) as in forehead samples (17/20). There was no increased prevalence of human papillomavirus in the cervix or mouth samples from the immunosuppressed patients.

Details

Authors
  • Peter Nordin
  • Bengt-Göran Hansson
  • Carita Hansson
  • Ingemar Blohme
  • Olle Larko
  • Kristin Andersson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Dermatology and Venereal Diseases

Keywords

  • polymerase chain, human papilloma virus, kidney transplant patients, squamous cell carcinoma, reaction
Original languageEnglish
Pages (from-to)219-222
JournalActa Dermato-Venereologica
Volume87
Issue number3
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes