Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy

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Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy. / Ljungberg, Michael; Sjögreen Gleisner, Katarina.

In: Diagnostics, Vol. 5, No. 3, 2015, p. 296-317.

Research output: Contribution to journalReview article

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TY - JOUR

T1 - Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy

AU - Ljungberg, Michael

AU - Sjögreen Gleisner, Katarina

PY - 2015

Y1 - 2015

N2 - Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and highlights the areas where hybrid imaging makes significant contributions.

AB - Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and highlights the areas where hybrid imaging makes significant contributions.

KW - dosimetry

KW - Monte Carlo

KW - SPECT

KW - hybrid

KW - CT

KW - absorbed dose

KW - therapy

KW - reconstruction

KW - quantitation

KW - activity

U2 - 10.3390/diagnostics5030296

DO - 10.3390/diagnostics5030296

M3 - Review article

C2 - 26854156

VL - 5

SP - 296

EP - 317

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 3

ER -