Hyperplasia and hypertrophia in the denervated and distended rat urinary bladder

Research output: Contribution to journalArticle


The parasympathetically denervated and distended rat urinary bladder was found to have increased fourfold in weight when examined 3 weeks postoperatively. Both in muscularis and mucosa of such a bladder the synthesis of proteins, RNA and DNA was increased severalfold. An increase in the polyamines putrescine, spermidine and spermine was also found; these polyamines are usually linked to protein synthesis. The results suggest that the cells of the two layers increase both in size and number. Hyperplasia was, in a previous study, suggested as a possible explanation for a right-ward shift of the active length-tension curve of muscle strips in the denervated rat urinary bladder.


  • J Ekström
  • Anne-Charlotte Henningsson
  • S Henningsson
  • Lars Malmberg
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology
  • Clinical Medicine
Original languageEnglish
Pages (from-to)45-48
JournalActa Physiologica Scandinavica
Issue number1
Publication statusPublished - 1984
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Urology, Lund (013077000), Pediatrics/Urology/Gynecology/Endocrinology (013240400)