Hyperplasia and hypertrophia in the denervated and distended rat urinary bladder
Research output: Contribution to journal › Article
The parasympathetically denervated and distended rat urinary bladder was found to have increased fourfold in weight when examined 3 weeks postoperatively. Both in muscularis and mucosa of such a bladder the synthesis of proteins, RNA and DNA was increased severalfold. An increase in the polyamines putrescine, spermidine and spermine was also found; these polyamines are usually linked to protein synthesis. The results suggest that the cells of the two layers increase both in size and number. Hyperplasia was, in a previous study, suggested as a possible explanation for a right-ward shift of the active length-tension curve of muscle strips in the denervated rat urinary bladder.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Acta Physiologica Scandinavica|
|Publication status||Published - 1984|
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Urology, Lund (013077000), Pediatrics/Urology/Gynecology/Endocrinology (013240400)