Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

Research output: Contribution to journalArticle


Background: Hyperthyroidism is a rare disorder which may negatively affect health and quality of life. Its occurrence in childhood cancer survivors has not previously been investigated in detail. Material and methods: In the hospital registers of the five Nordic countries, 32,944 childhood cancer survivors and 212,675 population comparisons were followed for the diagnosis of hyperthyroidism. Hospitalisation rates, standardised hospitalisation rate ratios and absolute excess risks were calculated with 95% confidence intervals (CI). Results: Hyperthyroidism was diagnosed in 131 childhood cancer survivors, yielding an overall relative risk of 1.6 (95% CI: 1.3–1.9) compared with population comparisons. The risk was greatest 1–5 years after the diagnosis of cancer and in survivors of thyroid cancers, neuroblastomas, acute lymphoblastic leukaemia and Hodgkin lymphoma. Sixty-seven percent of survivors with hyperthyroidism had tumours located in the head, neck or upper body and half of survivors with hyperthyroidism were irradiated with 77% of them in the head and neck area. Conclusion: Childhood cancer survivors are at an increased risk of hyperthyroidism, potentially resulting in non-endocrine morbidity.


  • Camilla T. Clausen
  • Henrik Hasle
  • Anna S. Holmqvist
  • Laura Madanat-Harjuoja
  • Laufey Tryggvadottir
  • Finn Wesenberg
  • Andrea Bautz
  • Jeanette F. Winther
  • Sofie de Fine Licht
External organisations
  • Danish Cancer Society Research Center
  • Aarhus University Hospital
  • Skåne University Hospital
  • Helsinki University Central Hospital
  • University of Iceland
  • Cancer Registry of Norway, Institute of Population-Based Cancer Research
  • Oslo university hospital
  • University of Oslo
  • Aarhus University
  • University of Helsinki
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Pediatrics
Original languageEnglish
Pages (from-to)227-231
JournalActa Oncologica
Issue number2
Early online date2018 Dec 26
Publication statusPublished - 2019
Publication categoryResearch