Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist

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Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. / Wieloch, Tadeusz.

In: Science, Vol. 230, No. 4726, 01.01.1985, p. 681-683.

Research output: Contribution to journalArticle

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TY - JOUR

T1 - Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist

AU - Wieloch, Tadeusz

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.

AB - The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1 week of recovery was reduced 90 percent compared to that in saline-injected animals. The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.

U2 - 10.1126/science.2996146

DO - 10.1126/science.2996146

M3 - Article

C2 - 2996146

AN - SCOPUS:0022344980

VL - 230

SP - 681

EP - 683

JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

SN - 1095-9203

IS - 4726

ER -