Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.

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Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues. / Renoux, Virginie; Zriwil, Alya; Peitzsch, Claudia; Michaëlsson, Jakob; Friberg, Danielle; Soneji, Shamit; Sitnicka Quinn, Ewa.

In: Immunity, Vol. 43, No. 2, 2015, p. 394-407.

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Renoux, Virginie ; Zriwil, Alya ; Peitzsch, Claudia ; Michaëlsson, Jakob ; Friberg, Danielle ; Soneji, Shamit ; Sitnicka Quinn, Ewa. / Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues. In: Immunity. 2015 ; Vol. 43, No. 2. pp. 394-407.

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TY - JOUR

T1 - Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.

AU - Renoux, Virginie

AU - Zriwil, Alya

AU - Peitzsch, Claudia

AU - Michaëlsson, Jakob

AU - Friberg, Danielle

AU - Soneji, Shamit

AU - Sitnicka Quinn, Ewa

PY - 2015

Y1 - 2015

N2 - Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues. The newly identified NKP has robust NK cell potential both in vitro and in vivo, generates functionally cytotoxic NK cells, and lacks the ability to produce T cells, B cells, myeloid cells, and innate lymphoid-like cells (ILCs). Our findings identify an early step to human NK cell commitment and provide new insights into the human hematopoietic hierarchy.

AB - Natural killer (NK) cells are cytotoxic lymphocytes and play a vital role in controlling viral infections and cancer. In contrast to B and T lymphopoiesis where cellular and regulatory pathways have been extensively characterized, the cellular stages of early human NK cell commitment remain poorly understood. Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues. The newly identified NKP has robust NK cell potential both in vitro and in vivo, generates functionally cytotoxic NK cells, and lacks the ability to produce T cells, B cells, myeloid cells, and innate lymphoid-like cells (ILCs). Our findings identify an early step to human NK cell commitment and provide new insights into the human hematopoietic hierarchy.

U2 - 10.1016/j.immuni.2015.07.011

DO - 10.1016/j.immuni.2015.07.011

M3 - Article

VL - 43

SP - 394

EP - 407

JO - Immunity

T2 - Immunity

JF - Immunity

SN - 1074-7613

IS - 2

ER -