Identification of a novel protease inhibitor gene that is highly expressed in the prostate.

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Abstract

A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.

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Subject classification (UKÄ) – MANDATORY

  • Biological Sciences

Keywords

  • Male, Molecular Sequence Data, Prostate : metabolism, Protease Inhibitors : chemistry, Protein Structure Tertiary, Reverse Transcriptase Polymerase Chain Reaction, Proteins : biosynthesis : chemistry : genetics, Sequence Analysis DNA, Sequence Homology Amino Acid, Sequence Homology Nucleic Acid, Tissue Distribution, Support Non-U.S. Gov't, Exons, Human, DNA Complementary : metabolism, Chromosomes Human Pair 20, Base Sequence, Amino Acid Sequence
Original languageEnglish
Pages (from-to)452-456
JournalBiochemical and Biophysical Research Communications
Volume290
Issue number1
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes