Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

Research output: Contribution to journalArticle

Abstract

B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.

Details

Authors
Organisations
External organisations
  • Karolinska Institutet
  • Skåne University Hospital
  • Danish Serum Institute, Copenhagen
  • Uppsala University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)682-690
JournalLeukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volume38
Issue number6
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

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