Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

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Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays. / Pauly, Frida; Smedby, Karin E; Jerkeman, Mats; Hjalgrim, Henrik; Ohlsson, Mattias; Rosenquist, Richard; Borrebaeck, Carl A K; Wingren, Christer.

In: Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis, Vol. 38, No. 6, 2014, p. 682-690.

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TY - JOUR

T1 - Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

AU - Pauly, Frida

AU - Smedby, Karin E

AU - Jerkeman, Mats

AU - Hjalgrim, Henrik

AU - Ohlsson, Mattias

AU - Rosenquist, Richard

AU - Borrebaeck, Carl A K

AU - Wingren, Christer

PY - 2014

Y1 - 2014

N2 - B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.

AB - B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.

U2 - 10.1016/j.leukres.2014.03.010

DO - 10.1016/j.leukres.2014.03.010

M3 - Article

VL - 38

SP - 682

EP - 690

JO - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

T2 - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

JF - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

SN - 1873-5835

IS - 6

ER -