Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Research output: Contribution to journalArticle

Standard

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. / Couch, Fergus J; Kuchenbaecker, Karoline B.; Michailidou, Kyriaki; Mendoza-Fandino, Gustavo A.; Nord, Silje; Lilyquist, Janna; Olswold, Curtis; Hallberg, Emily; Agata, Simona; Ahsan, Habibul; Aittomäki, Kristiina; Ambrosone, Christine; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Arun, Banu K.; Arver, Brita; Barile, Monica; Barkardottir, Rosa B.; Barrowdale, Daniel; Beckmann, Lars; Beckmann, Matthias W; Benitez, Javier; Blank, Stephanie V.; Blomqvist, Carl; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Brauch, Hiltrud; Brenner, Hermann; Burwinkel, Barbara; Buys, Saundra; Caldes, Trinidad; Caligo, Maria A.; Canzian, Federico; Carpenter, Jane; Chang-Claude, Jenny; Chanock, Stephen J; Chung, Wendy K.; Claes, Kathleen B M; Cox, Angela; Cross, Simon S; Cunningham, Julie M.; Czene, Kamila; Daly, Mary B.; Damiola, Francesca; Darabi, Hatef; de la Hoya, Miguel; Devilee, Peter; Diez, Orland; Ding, Yuan C.; Dolcetti, Riccardo; Domchek, Susan M; Dorfling, Cecilia M.; Dos Santos Silva, Isabel; Dumont, Martine; Dunning, Alison M.; Eccles, Diana M.; Ehrencrona, Hans; Ekici, Arif B; Eliassen, A Heather; Ellis, Steve; Fasching, Peter A; Figueroa, Jonine; Flesch-Janys, Dieter; Försti, Asta; Fostira, Florentia; Foulkes, William D; Friebel, Tara; Friedman, Eitan; Frost, Debra; Gabrielson, Marike; Gammon, Marilie D.; Ganz, Patricia A.; Gapstur, Susan M; Garber, Judy; Gaudet, Mia; Gayther, Simon A.; Gerdes, Anne-Marie; Ghoussaini, Maya; Giles, Graham G; Glendon, Gord; Godwin, Andrew K; Goldberg, Mark S; Goldgar, David E.; González-Neira, Anna; Greene, Mark H; Gronwald, Jacek; Guénel, Pascal; Gunter, Marc; Haeberle, Lothar; Haiman, Christopher A.; Hamann, Ute; Hansen, Thomas V. O.; Hart, Steven; Healey, Sue; Heikkinen, Tuomas; Henderson, Brian E.; Herzog, Josef; Hogervorst, Frans B. L.; Hollestelle, Antoinette; Hooning, Maartje J.; Hoover, Robert N.; Hopper, John L; Humphreys, Keith; Hunter, David J; Huzarski, Tomasz; Imyanitov, Evgeny N; Isaacs, Claudine; Jakubowska, Anna; James, Paul; Janavicius, Ramunas; Jensen, Uffe Birk; John, Esther M.; Jones, Michael; Kabisch, Maria; Kar, Siddhartha; Karlan, Beth Y.; Khan, Sofia; Khaw, Kay Tee; Kibriya, Muhammad G; Knight, Julia A; Ko, Yon-Dschun; Konstantopoulou, Irene; Kosma, Veli-Matti; Kristensen, Vessela; Kwong, Ava; Laitman, Yael; Lambrechts, Diether; Lazaro, Conxi; Lee, Eunjung; Le Marchand, Loic; Lester, Jenny; Lindblom, Annika; Lindor, Noralane; Lindstrom, Sara; Liu, Jianjun; Long, Jirong; Lubinski, Jan; Mai, Phuong L; Makalic, Enes; Malone, Kathleen E; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Marme, Frederik; Martens, John W M; McGuffog, Lesley; Meindl, Alfons; Miller, Austin; Milne, Roger L.; Miron, Penelope; Montagna, Marco; Mazoyer, Sylvie; Mulligan, Anna Marie; Muranen, Taru A.; Nathanson, Katherine L; Neuhausen, Susan L.; Nevanlinna, Heli; Nordestgaard, Børge G; Nussbaum, Robert L; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I.; Olson, Janet E; Osorio, Ana; Park, Sue K.; Peeters, Petra H.; Peissel, Bernard; Peterlongo, Paolo; Peto, Julian; Phelan, Catherine M.; Pilarski, Robert; Poppe, Bruce; Pylkäs, Katri; Radice, Paolo; Rahman, Nazneen; Rantala, Johanna; Rappaport, Christine; Rennert, Gad; Richardson, Andrea L.; Robson, Mark; Romieu, Isabelle; Rudolph, Anja; Rutgers, Emiel J.; Sanchez, Maria-Jose; Santella, Regina M.; Sawyer, Elinor J; Schmidt, Daniel F.; Schmidt, Marjanka K; Schmutzler, Rita K; Schumacher, Fredrick; Scott, Rodney; Senter, Leigha; Sharma, Priyanka; Simard, Jacques; Singer, Christian F.; Sinilnikova, Olga M; Soucy, Penny; Southey, Melissa; Steinemann, Doris; Stenmark-Askmalm, Marie; Stoppa-Lyonnet, Dominique; Swerdlow, Anthony; Szabo, Csilla I; Tamimi, Rulla; Tapper, William; Teixeira, Manuel R; Teo, Soo-Hwang; Terry, Mary B.; Thomassen, Mads; Thompson, Deborah; Tihomirova, Laima; Toland, Amanda E; Tollenaar, Robert A E M; Tomlinson, Ian; Truong, Thérèse; Tsimiklis, Helen; Teulé, Alex; Tumino, Rosario; Tung, Nadine; Turnbull, Clare; Ursin, Giski; van Deurzen, Carolien H. M.; van Rensburg, Elizabeth J.; Varon-Mateeva, Raymonda; Wang, Zhaoming; Wang-Gohrke, Shan; Weiderpass, Elisabete; Weitzel, Jeffrey N.; Whittemore, Alice S.; Wildiers, Hans; Winqvist, Robert; Yang, Xiaohong R; Yannoukakos, Drakoulis; Yao, Song; Zamora, M Pilar; Zheng, Wei; Hall, Per; Kraft, Peter; Vachon, Celine; Slager, Susan; Chenevix-Trench, Georgia; Pharoah, Paul P. D.; Monteiro, Alvaro N; García-Closas, Montserrat; Easton, Douglas F; Antoniou, Antonis C.

In: Nature Communications, Vol. 7, 11375, 27.04.2016.

Research output: Contribution to journalArticle

Harvard

Couch, FJ, Kuchenbaecker, KB, Michailidou, K, Mendoza-Fandino, GA, Nord, S, Lilyquist, J, Olswold, C, Hallberg, E, Agata, S, Ahsan, H, Aittomäki, K, Ambrosone, C, Andrulis, IL, Anton-Culver, H, Arndt, V, Arun, BK, Arver, B, Barile, M, Barkardottir, RB, Barrowdale, D, Beckmann, L, Beckmann, MW, Benitez, J, Blank, SV, Blomqvist, C, Bogdanova, NV, Bojesen, SE, Bolla, MK, Bonanni, B, Brauch, H, Brenner, H, Burwinkel, B, Buys, S, Caldes, T, Caligo, MA, Canzian, F, Carpenter, J, Chang-Claude, J, Chanock, SJ, Chung, WK, Claes, KBM, Cox, A, Cross, SS, Cunningham, JM, Czene, K, Daly, MB, Damiola, F, Darabi, H, de la Hoya, M, Devilee, P, Diez, O, Ding, YC, Dolcetti, R, Domchek, SM, Dorfling, CM, Dos Santos Silva, I, Dumont, M, Dunning, AM, Eccles, DM, Ehrencrona, H, Ekici, AB, Eliassen, AH, Ellis, S, Fasching, PA, Figueroa, J, Flesch-Janys, D, Försti, A, Fostira, F, Foulkes, WD, Friebel, T, Friedman, E, Frost, D, Gabrielson, M, Gammon, MD, Ganz, PA, Gapstur, SM, Garber, J, Gaudet, M, Gayther, SA, Gerdes, A-M, Ghoussaini, M, Giles, GG, Glendon, G, Godwin, AK, Goldberg, MS, Goldgar, DE, González-Neira, A, Greene, MH, Gronwald, J, Guénel, P, Gunter, M, Haeberle, L, Haiman, CA, Hamann, U, Hansen, TVO, Hart, S, Healey, S, Heikkinen, T, Henderson, BE, Herzog, J, Hogervorst, FBL, Hollestelle, A, Hooning, MJ, Hoover, RN, Hopper, JL, Humphreys, K, Hunter, DJ, Huzarski, T, Imyanitov, EN, Isaacs, C, Jakubowska, A, James, P, Janavicius, R, Jensen, UB, John, EM, Jones, M, Kabisch, M, Kar, S, Karlan, BY, Khan, S, Khaw, KT, Kibriya, MG, Knight, JA, Ko, Y-D, Konstantopoulou, I, Kosma, V-M, Kristensen, V, Kwong, A, Laitman, Y, Lambrechts, D, Lazaro, C, Lee, E, Le Marchand, L, Lester, J, Lindblom, A, Lindor, N, Lindstrom, S, Liu, J, Long, J, Lubinski, J, Mai, PL, Makalic, E, Malone, KE, Mannermaa, A, Manoukian, S, Margolin, S, Marme, F, Martens, JWM, McGuffog, L, Meindl, A, Miller, A, Milne, RL, Miron, P, Montagna, M, Mazoyer, S, Mulligan, AM, Muranen, TA, Nathanson, KL, Neuhausen, SL, Nevanlinna, H, Nordestgaard, BG, Nussbaum, RL, Offit, K, Olah, E, Olopade, OI, Olson, JE, Osorio, A, Park, SK, Peeters, PH, Peissel, B, Peterlongo, P, Peto, J, Phelan, CM, Pilarski, R, Poppe, B, Pylkäs, K, Radice, P, Rahman, N, Rantala, J, Rappaport, C, Rennert, G, Richardson, AL, Robson, M, Romieu, I, Rudolph, A, Rutgers, EJ, Sanchez, M-J, Santella, RM, Sawyer, EJ, Schmidt, DF, Schmidt, MK, Schmutzler, RK, Schumacher, F, Scott, R, Senter, L, Sharma, P, Simard, J, Singer, CF, Sinilnikova, OM, Soucy, P, Southey, M, Steinemann, D, Stenmark-Askmalm, M, Stoppa-Lyonnet, D, Swerdlow, A, Szabo, CI, Tamimi, R, Tapper, W, Teixeira, MR, Teo, S-H, Terry, MB, Thomassen, M, Thompson, D, Tihomirova, L, Toland, AE, Tollenaar, RAEM, Tomlinson, I, Truong, T, Tsimiklis, H, Teulé, A, Tumino, R, Tung, N, Turnbull, C, Ursin, G, van Deurzen, CHM, van Rensburg, EJ, Varon-Mateeva, R, Wang, Z, Wang-Gohrke, S, Weiderpass, E, Weitzel, JN, Whittemore, AS, Wildiers, H, Winqvist, R, Yang, XR, Yannoukakos, D, Yao, S, Zamora, MP, Zheng, W, Hall, P, Kraft, P, Vachon, C, Slager, S, Chenevix-Trench, G, Pharoah, PPD, Monteiro, AN, García-Closas, M, Easton, DF & Antoniou, AC 2016, 'Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer', Nature Communications, vol. 7, 11375. https://doi.org/10.1038/ncomms11375

APA

Couch, F. J., Kuchenbaecker, K. B., Michailidou, K., Mendoza-Fandino, G. A., Nord, S., Lilyquist, J., ... Antoniou, A. C. (2016). Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Nature Communications, 7, [11375]. https://doi.org/10.1038/ncomms11375

CBE

Couch FJ, Kuchenbaecker KB, Michailidou K, Mendoza-Fandino GA, Nord S, Lilyquist J, Olswold C, Hallberg E, Agata S, Ahsan H, Aittomäki K, Ambrosone C, Andrulis IL, Anton-Culver H, Arndt V, Arun BK, Arver B, Barile M, Barkardottir RB, Barrowdale D, Beckmann L, Beckmann MW, Benitez J, Blank SV, Blomqvist C, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Brauch H, Brenner H, Burwinkel B, Buys S, Caldes T, Caligo MA, Canzian F, Carpenter J, Chang-Claude J, Chanock SJ, Chung WK, Claes KBM, Cox A, Cross SS, Cunningham JM, Czene K, Daly MB, Damiola F, Darabi H, de la Hoya M, Devilee P, Diez O, Ding YC, Dolcetti R, Domchek SM, Dorfling CM, Dos Santos Silva I, Dumont M, Dunning AM, Eccles DM, Ehrencrona H, Ekici AB, Eliassen AH, Ellis S, Fasching PA, Figueroa J, Flesch-Janys D, Försti A, Fostira F, Foulkes WD, Friebel T, Friedman E, Frost D, Gabrielson M, Gammon MD, Ganz PA, Gapstur SM, Garber J, Gaudet M, Gayther SA, Gerdes A-M, Ghoussaini M, Giles GG, Glendon G, Godwin AK, Goldberg MS, Goldgar DE, González-Neira A, Greene MH, Gronwald J, Guénel P, Gunter M, Haeberle L, Haiman CA, Hamann U, Hansen TVO, Hart S, Healey S, Heikkinen T, Henderson BE, Herzog J, Hogervorst FBL, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Humphreys K, Hunter DJ, Huzarski T, Imyanitov EN, Isaacs C, Jakubowska A, James P, Janavicius R, Jensen UB, John EM, Jones M, Kabisch M, Kar S, Karlan BY, Khan S, Khaw KT, Kibriya MG, Knight JA, Ko Y-D, Konstantopoulou I, Kosma V-M, Kristensen V, Kwong A, Laitman Y, Lambrechts D, Lazaro C, Lee E, Le Marchand L, Lester J, Lindblom A, Lindor N, Lindstrom S, Liu J, Long J, Lubinski J, Mai PL, Makalic E, Malone KE, Mannermaa A, Manoukian S, Margolin S, Marme F, Martens JWM, McGuffog L, Meindl A, Miller A, Milne RL, Miron P, Montagna M, Mazoyer S, Mulligan AM, Muranen TA, Nathanson KL, Neuhausen SL, Nevanlinna H, Nordestgaard BG, Nussbaum RL, Offit K, Olah E, Olopade OI, Olson JE, Osorio A, Park SK, Peeters PH, Peissel B, Peterlongo P, Peto J, Phelan CM, Pilarski R, Poppe B, Pylkäs K, Radice P, Rahman N, Rantala J, Rappaport C, Rennert G, Richardson AL, Robson M, Romieu I, Rudolph A, Rutgers EJ, Sanchez M-J, Santella RM, Sawyer EJ, Schmidt DF, Schmidt MK, Schmutzler RK, Schumacher F, Scott R, Senter L, Sharma P, Simard J, Singer CF, Sinilnikova OM, Soucy P, Southey M, Steinemann D, Stenmark-Askmalm M, Stoppa-Lyonnet D, Swerdlow A, Szabo CI, Tamimi R, Tapper W, Teixeira MR, Teo S-H, Terry MB, Thomassen M, Thompson D, Tihomirova L, Toland AE, Tollenaar RAEM, Tomlinson I, Truong T, Tsimiklis H, Teulé A, Tumino R, Tung N, Turnbull C, Ursin G, van Deurzen CHM, van Rensburg EJ, Varon-Mateeva R, Wang Z, Wang-Gohrke S, Weiderpass E, Weitzel JN, Whittemore AS, Wildiers H, Winqvist R, Yang XR, Yannoukakos D, Yao S, Zamora MP, Zheng W, Hall P, Kraft P, Vachon C, Slager S, Chenevix-Trench G, Pharoah PPD, Monteiro AN, García-Closas M, Easton DF, Antoniou AC. 2016. Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Nature Communications. 7. https://doi.org/10.1038/ncomms11375

MLA

Vancouver

Couch FJ, Kuchenbaecker KB, Michailidou K, Mendoza-Fandino GA, Nord S, Lilyquist J et al. Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Nature Communications. 2016 Apr 27;7. 11375. https://doi.org/10.1038/ncomms11375

Author

Couch, Fergus J ; Kuchenbaecker, Karoline B. ; Michailidou, Kyriaki ; Mendoza-Fandino, Gustavo A. ; Nord, Silje ; Lilyquist, Janna ; Olswold, Curtis ; Hallberg, Emily ; Agata, Simona ; Ahsan, Habibul ; Aittomäki, Kristiina ; Ambrosone, Christine ; Andrulis, Irene L ; Anton-Culver, Hoda ; Arndt, Volker ; Arun, Banu K. ; Arver, Brita ; Barile, Monica ; Barkardottir, Rosa B. ; Barrowdale, Daniel ; Beckmann, Lars ; Beckmann, Matthias W ; Benitez, Javier ; Blank, Stephanie V. ; Blomqvist, Carl ; Bogdanova, Natalia V ; Bojesen, Stig E ; Bolla, Manjeet K ; Bonanni, Bernardo ; Brauch, Hiltrud ; Brenner, Hermann ; Burwinkel, Barbara ; Buys, Saundra ; Caldes, Trinidad ; Caligo, Maria A. ; Canzian, Federico ; Carpenter, Jane ; Chang-Claude, Jenny ; Chanock, Stephen J ; Chung, Wendy K. ; Claes, Kathleen B M ; Cox, Angela ; Cross, Simon S ; Cunningham, Julie M. ; Czene, Kamila ; Daly, Mary B. ; Damiola, Francesca ; Darabi, Hatef ; de la Hoya, Miguel ; Devilee, Peter ; Diez, Orland ; Ding, Yuan C. ; Dolcetti, Riccardo ; Domchek, Susan M ; Dorfling, Cecilia M. ; Dos Santos Silva, Isabel ; Dumont, Martine ; Dunning, Alison M. ; Eccles, Diana M. ; Ehrencrona, Hans ; Ekici, Arif B ; Eliassen, A Heather ; Ellis, Steve ; Fasching, Peter A ; Figueroa, Jonine ; Flesch-Janys, Dieter ; Försti, Asta ; Fostira, Florentia ; Foulkes, William D ; Friebel, Tara ; Friedman, Eitan ; Frost, Debra ; Gabrielson, Marike ; Gammon, Marilie D. ; Ganz, Patricia A. ; Gapstur, Susan M ; Garber, Judy ; Gaudet, Mia ; Gayther, Simon A. ; Gerdes, Anne-Marie ; Ghoussaini, Maya ; Giles, Graham G ; Glendon, Gord ; Godwin, Andrew K ; Goldberg, Mark S ; Goldgar, David E. ; González-Neira, Anna ; Greene, Mark H ; Gronwald, Jacek ; Guénel, Pascal ; Gunter, Marc ; Haeberle, Lothar ; Haiman, Christopher A. ; Hamann, Ute ; Hansen, Thomas V. O. ; Hart, Steven ; Healey, Sue ; Heikkinen, Tuomas ; Henderson, Brian E. ; Herzog, Josef ; Hogervorst, Frans B. L. ; Hollestelle, Antoinette ; Hooning, Maartje J. ; Hoover, Robert N. ; Hopper, John L ; Humphreys, Keith ; Hunter, David J ; Huzarski, Tomasz ; Imyanitov, Evgeny N ; Isaacs, Claudine ; Jakubowska, Anna ; James, Paul ; Janavicius, Ramunas ; Jensen, Uffe Birk ; John, Esther M. ; Jones, Michael ; Kabisch, Maria ; Kar, Siddhartha ; Karlan, Beth Y. ; Khan, Sofia ; Khaw, Kay Tee ; Kibriya, Muhammad G ; Knight, Julia A ; Ko, Yon-Dschun ; Konstantopoulou, Irene ; Kosma, Veli-Matti ; Kristensen, Vessela ; Kwong, Ava ; Laitman, Yael ; Lambrechts, Diether ; Lazaro, Conxi ; Lee, Eunjung ; Le Marchand, Loic ; Lester, Jenny ; Lindblom, Annika ; Lindor, Noralane ; Lindstrom, Sara ; Liu, Jianjun ; Long, Jirong ; Lubinski, Jan ; Mai, Phuong L ; Makalic, Enes ; Malone, Kathleen E ; Mannermaa, Arto ; Manoukian, Siranoush ; Margolin, Sara ; Marme, Frederik ; Martens, John W M ; McGuffog, Lesley ; Meindl, Alfons ; Miller, Austin ; Milne, Roger L. ; Miron, Penelope ; Montagna, Marco ; Mazoyer, Sylvie ; Mulligan, Anna Marie ; Muranen, Taru A. ; Nathanson, Katherine L ; Neuhausen, Susan L. ; Nevanlinna, Heli ; Nordestgaard, Børge G ; Nussbaum, Robert L ; Offit, Kenneth ; Olah, Edith ; Olopade, Olufunmilayo I. ; Olson, Janet E ; Osorio, Ana ; Park, Sue K. ; Peeters, Petra H. ; Peissel, Bernard ; Peterlongo, Paolo ; Peto, Julian ; Phelan, Catherine M. ; Pilarski, Robert ; Poppe, Bruce ; Pylkäs, Katri ; Radice, Paolo ; Rahman, Nazneen ; Rantala, Johanna ; Rappaport, Christine ; Rennert, Gad ; Richardson, Andrea L. ; Robson, Mark ; Romieu, Isabelle ; Rudolph, Anja ; Rutgers, Emiel J. ; Sanchez, Maria-Jose ; Santella, Regina M. ; Sawyer, Elinor J ; Schmidt, Daniel F. ; Schmidt, Marjanka K ; Schmutzler, Rita K ; Schumacher, Fredrick ; Scott, Rodney ; Senter, Leigha ; Sharma, Priyanka ; Simard, Jacques ; Singer, Christian F. ; Sinilnikova, Olga M ; Soucy, Penny ; Southey, Melissa ; Steinemann, Doris ; Stenmark-Askmalm, Marie ; Stoppa-Lyonnet, Dominique ; Swerdlow, Anthony ; Szabo, Csilla I ; Tamimi, Rulla ; Tapper, William ; Teixeira, Manuel R ; Teo, Soo-Hwang ; Terry, Mary B. ; Thomassen, Mads ; Thompson, Deborah ; Tihomirova, Laima ; Toland, Amanda E ; Tollenaar, Robert A E M ; Tomlinson, Ian ; Truong, Thérèse ; Tsimiklis, Helen ; Teulé, Alex ; Tumino, Rosario ; Tung, Nadine ; Turnbull, Clare ; Ursin, Giski ; van Deurzen, Carolien H. M. ; van Rensburg, Elizabeth J. ; Varon-Mateeva, Raymonda ; Wang, Zhaoming ; Wang-Gohrke, Shan ; Weiderpass, Elisabete ; Weitzel, Jeffrey N. ; Whittemore, Alice S. ; Wildiers, Hans ; Winqvist, Robert ; Yang, Xiaohong R ; Yannoukakos, Drakoulis ; Yao, Song ; Zamora, M Pilar ; Zheng, Wei ; Hall, Per ; Kraft, Peter ; Vachon, Celine ; Slager, Susan ; Chenevix-Trench, Georgia ; Pharoah, Paul P. D. ; Monteiro, Alvaro N ; García-Closas, Montserrat ; Easton, Douglas F ; Antoniou, Antonis C. / Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. In: Nature Communications. 2016 ; Vol. 7.

RIS

TY - JOUR

T1 - Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

AU - Couch, Fergus J

AU - Kuchenbaecker, Karoline B.

AU - Michailidou, Kyriaki

AU - Mendoza-Fandino, Gustavo A.

AU - Nord, Silje

AU - Lilyquist, Janna

AU - Olswold, Curtis

AU - Hallberg, Emily

AU - Agata, Simona

AU - Ahsan, Habibul

AU - Aittomäki, Kristiina

AU - Ambrosone, Christine

AU - Andrulis, Irene L

AU - Anton-Culver, Hoda

AU - Arndt, Volker

AU - Arun, Banu K.

AU - Arver, Brita

AU - Barile, Monica

AU - Barkardottir, Rosa B.

AU - Barrowdale, Daniel

AU - Beckmann, Lars

AU - Beckmann, Matthias W

AU - Benitez, Javier

AU - Blank, Stephanie V.

AU - Blomqvist, Carl

AU - Bogdanova, Natalia V

AU - Bojesen, Stig E

AU - Bolla, Manjeet K

AU - Bonanni, Bernardo

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Burwinkel, Barbara

AU - Buys, Saundra

AU - Caldes, Trinidad

AU - Caligo, Maria A.

AU - Canzian, Federico

AU - Carpenter, Jane

AU - Chang-Claude, Jenny

AU - Chanock, Stephen J

AU - Chung, Wendy K.

AU - Claes, Kathleen B M

AU - Cox, Angela

AU - Cross, Simon S

AU - Cunningham, Julie M.

AU - Czene, Kamila

AU - Daly, Mary B.

AU - Damiola, Francesca

AU - Darabi, Hatef

AU - de la Hoya, Miguel

AU - Devilee, Peter

AU - Diez, Orland

AU - Ding, Yuan C.

AU - Dolcetti, Riccardo

AU - Domchek, Susan M

AU - Dorfling, Cecilia M.

AU - Dos Santos Silva, Isabel

AU - Dumont, Martine

AU - Dunning, Alison M.

AU - Eccles, Diana M.

AU - Ehrencrona, Hans

AU - Ekici, Arif B

AU - Eliassen, A Heather

AU - Ellis, Steve

AU - Fasching, Peter A

AU - Figueroa, Jonine

AU - Flesch-Janys, Dieter

AU - Försti, Asta

AU - Fostira, Florentia

AU - Foulkes, William D

AU - Friebel, Tara

AU - Friedman, Eitan

AU - Frost, Debra

AU - Gabrielson, Marike

AU - Gammon, Marilie D.

AU - Ganz, Patricia A.

AU - Gapstur, Susan M

AU - Garber, Judy

AU - Gaudet, Mia

AU - Gayther, Simon A.

AU - Gerdes, Anne-Marie

AU - Ghoussaini, Maya

AU - Giles, Graham G

AU - Glendon, Gord

AU - Godwin, Andrew K

AU - Goldberg, Mark S

AU - Goldgar, David E.

AU - González-Neira, Anna

AU - Greene, Mark H

AU - Gronwald, Jacek

AU - Guénel, Pascal

AU - Gunter, Marc

AU - Haeberle, Lothar

AU - Haiman, Christopher A.

AU - Hamann, Ute

AU - Hansen, Thomas V. O.

AU - Hart, Steven

AU - Healey, Sue

AU - Heikkinen, Tuomas

AU - Henderson, Brian E.

AU - Herzog, Josef

AU - Hogervorst, Frans B. L.

AU - Hollestelle, Antoinette

AU - Hooning, Maartje J.

AU - Hoover, Robert N.

AU - Hopper, John L

AU - Humphreys, Keith

AU - Hunter, David J

AU - Huzarski, Tomasz

AU - Imyanitov, Evgeny N

AU - Isaacs, Claudine

AU - Jakubowska, Anna

AU - James, Paul

AU - Janavicius, Ramunas

AU - Jensen, Uffe Birk

AU - John, Esther M.

AU - Jones, Michael

AU - Kabisch, Maria

AU - Kar, Siddhartha

AU - Karlan, Beth Y.

AU - Khan, Sofia

AU - Khaw, Kay Tee

AU - Kibriya, Muhammad G

AU - Knight, Julia A

AU - Ko, Yon-Dschun

AU - Konstantopoulou, Irene

AU - Kosma, Veli-Matti

AU - Kristensen, Vessela

AU - Kwong, Ava

AU - Laitman, Yael

AU - Lambrechts, Diether

AU - Lazaro, Conxi

AU - Lee, Eunjung

AU - Le Marchand, Loic

AU - Lester, Jenny

AU - Lindblom, Annika

AU - Lindor, Noralane

AU - Lindstrom, Sara

AU - Liu, Jianjun

AU - Long, Jirong

AU - Lubinski, Jan

AU - Mai, Phuong L

AU - Makalic, Enes

AU - Malone, Kathleen E

AU - Mannermaa, Arto

AU - Manoukian, Siranoush

AU - Margolin, Sara

AU - Marme, Frederik

AU - Martens, John W M

AU - McGuffog, Lesley

AU - Meindl, Alfons

AU - Miller, Austin

AU - Milne, Roger L.

AU - Miron, Penelope

AU - Montagna, Marco

AU - Mazoyer, Sylvie

AU - Mulligan, Anna Marie

AU - Muranen, Taru A.

AU - Nathanson, Katherine L

AU - Neuhausen, Susan L.

AU - Nevanlinna, Heli

AU - Nordestgaard, Børge G

AU - Nussbaum, Robert L

AU - Offit, Kenneth

AU - Olah, Edith

AU - Olopade, Olufunmilayo I.

AU - Olson, Janet E

AU - Osorio, Ana

AU - Park, Sue K.

AU - Peeters, Petra H.

AU - Peissel, Bernard

AU - Peterlongo, Paolo

AU - Peto, Julian

AU - Phelan, Catherine M.

AU - Pilarski, Robert

AU - Poppe, Bruce

AU - Pylkäs, Katri

AU - Radice, Paolo

AU - Rahman, Nazneen

AU - Rantala, Johanna

AU - Rappaport, Christine

AU - Rennert, Gad

AU - Richardson, Andrea L.

AU - Robson, Mark

AU - Romieu, Isabelle

AU - Rudolph, Anja

AU - Rutgers, Emiel J.

AU - Sanchez, Maria-Jose

AU - Santella, Regina M.

AU - Sawyer, Elinor J

AU - Schmidt, Daniel F.

AU - Schmidt, Marjanka K

AU - Schmutzler, Rita K

AU - Schumacher, Fredrick

AU - Scott, Rodney

AU - Senter, Leigha

AU - Sharma, Priyanka

AU - Simard, Jacques

AU - Singer, Christian F.

AU - Sinilnikova, Olga M

AU - Soucy, Penny

AU - Southey, Melissa

AU - Steinemann, Doris

AU - Stenmark-Askmalm, Marie

AU - Stoppa-Lyonnet, Dominique

AU - Swerdlow, Anthony

AU - Szabo, Csilla I

AU - Tamimi, Rulla

AU - Tapper, William

AU - Teixeira, Manuel R

AU - Teo, Soo-Hwang

AU - Terry, Mary B.

AU - Thomassen, Mads

AU - Thompson, Deborah

AU - Tihomirova, Laima

AU - Toland, Amanda E

AU - Tollenaar, Robert A E M

AU - Tomlinson, Ian

AU - Truong, Thérèse

AU - Tsimiklis, Helen

AU - Teulé, Alex

AU - Tumino, Rosario

AU - Tung, Nadine

AU - Turnbull, Clare

AU - Ursin, Giski

AU - van Deurzen, Carolien H. M.

AU - van Rensburg, Elizabeth J.

AU - Varon-Mateeva, Raymonda

AU - Wang, Zhaoming

AU - Wang-Gohrke, Shan

AU - Weiderpass, Elisabete

AU - Weitzel, Jeffrey N.

AU - Whittemore, Alice S.

AU - Wildiers, Hans

AU - Winqvist, Robert

AU - Yang, Xiaohong R

AU - Yannoukakos, Drakoulis

AU - Yao, Song

AU - Zamora, M Pilar

AU - Zheng, Wei

AU - Hall, Per

AU - Kraft, Peter

AU - Vachon, Celine

AU - Slager, Susan

AU - Chenevix-Trench, Georgia

AU - Pharoah, Paul P. D.

AU - Monteiro, Alvaro N

AU - García-Closas, Montserrat

AU - Easton, Douglas F

AU - Antoniou, Antonis C

PY - 2016/4/27

Y1 - 2016/4/27

N2 - Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10-8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.

AB - Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10-8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.

UR - http://www.scopus.com/inward/record.url?scp=84968760294&partnerID=8YFLogxK

U2 - 10.1038/ncomms11375

DO - 10.1038/ncomms11375

M3 - Article

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 11375

ER -