Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Research output: Contribution to journalArticle

Standard

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. / den Hoed, Marcel; Eijgelsheim, Mark; Esko, Tonu; Brundel, Bianca J. J. M.; Peal, David S.; Evans, David M.; Nolte, Ilja M.; Segre, Ayellet V.; Holm, Hilma; Handsaker, Robert E.; Westra, Harm-Jan; Johnson, Toby; Isaacs, Aaron; Yang, Jian; Lundby, Alicia; Zhao, Jing Hua; Kim, Young Jin; Go, Min Jin; Almgren, Peter; Bochud, Murielle; Boucher, Gabrielle; Cornelis, Marilyn C.; Gudbjartsson, Daniel; Hadley, David; van der Harst, Pim; Hayward, Caroline; den Heijer, Martin; Igl, Wilmar; Jackson, Anne U.; Kutalik, Zoltan; Luan, Jian'an; Kemp, John P.; Kristiansson, Kati; Ladenvall, Claes; Lorentzon, Mattias; Montasser, May E.; Njajou, Omer T.; O'Reilly, Paul F.; Padmanabhan, Sandosh; Pourcain, Beate St.; Rankinen, Tuomo; Salo, Perttu; Tanaka, Toshiko; Timpson, Nicholas J.; Vitart, Veronique; Waite, Lindsay; Wheeler, William; Zhang, Weihua; Draisma, Harmen H. M.; Feitosa, Mary F.; Kerr, Kathleen F.; Lind, Penelope A.; Mihailov, Evelin; Onland-Moret, N. Charlotte; Song, Ci; Weedon, Michael N.; Xie, Weijia; Yengo, Loic; Absher, Devin; Albert, Christine M.; Alonso, Alvaro; Arking, Dan E.; de Bakker, Paul I. W.; Balkau, Beverley; Barlassina, Cristina; Benaglio, Paola; Bis, Joshua C.; Bouatia-Naji, Nabila; Brage, Soren; Chanock, Stephen J.; Chines, Peter S.; Chung, Mina; Darbar, Dawood; Dina, Christian; Doerr, Marcus; Elliott, Paul; Felix, Stephan B.; Fischer, Krista; Fuchsberger, Christian; de Geus, Eco J. C.; Goyette, Philippe; Gudnason, Vilmundur; Harris, Tamara B.; Hartikainen, Anna-Liisa; Havulinna, Aki S.; Heckbert, Susan R.; Hicks, Andrew A.; Hofman, Albert; Holewijn, Suzanne; Hoogstra-Berends, Femke; Hottenga, Jouke-Jan; Jensen, Majken K.; Johansson, Asa; Junttila, Juhani; Kaeaeb, Stefan; Kanon, Bart; Ketkar, Shamika; Khaw, Kay-Tee; Knowles, Joshua W.; Kooner, Angrad S.; Kors, Jan A.; Kumari, Meena; Milani, Lili; Laiho, Paeivi; Lakatta, Edward G.; Langenberg, Claudia; Leusink, Maarten; Liu, Yongmei; Luben, Robert N.; Lunetta, Kathryn L.; Lynch, Stacey N.; Markus, Marcello R. P.; Marques-Vidal, Pedro; Leach, Irene Mateo; McArdle, Wendy L.; McCarroll, Steven A.; Medland, Sarah E.; Miller, Kathryn A.; Montgomery, Grant W.; Morrison, Alanna C.; Mueller-Nurasyid, Martina; Navarro, Pau; Nelis, Mari; O'Connell, Jeffrey R.; O'Donnell, Christopher J.; Ong, Ken K.; Newman, Anne B.; Peters, Annette; Polasek, Ozren; Pouta, Anneli; Pramstaller, Peter P.; Psaty, Bruce M.; Rao, Dabeeru C.; Ring, Susan M.; Rossin, Elizabeth J.; Rudan, Diana; Sanna, Serena; Scott, Robert A.; Sehmi, Jaban S.; Sharp, Stephen; Shin, Jordan T.; Singleton, Andrew B.; Smith, Albert V.; Soranzo, Nicole; Spector, Tim D.; Stewart, Chip; Stringham, Heather M.; Tarasov, Kirill V.; Uitterlinden, Andre G.; Vandenput, Liesbeth; Hwang, Shih-Jen; Whitfield, John B.; Wijmenga, Cisca; Wild, Sarah H.; Willemsen, Gonneke; Wilson, James F.; Witteman, Jacqueline C. M.; Wong, Andrew; Wong, Quenna; Jamshidi, Yalda; Zitting, Paavo; Boer, Jolanda M. A.; Boomsma, Dorret I.; Borecki, Ingrid B.; van Duijn, Cornelia M.; Ekelund, Ulf; Forouhi, Nita G.; Froguel, Philippe; Hingorani, Aroon; Ingelsson, Erik; Kivimaki, Mika; Kronmal, Richard A.; Kuh, Diana; Lind, Lars; Martin, Nicholas G.; Oostra, Ben A.; Pedersen, Nancy L.; Quertermous, Thomas; Rotter, Jerome I.; van der Schouw, Yvonne T.; Verschuren, W. M. Monique; Walker, Mark; Albanes, Demetrius; Arnar, David O.; Assimes, Themistocles L.; Bandinelli, Stefania; Boehnke, Michael; de Boer, Rudolf A.; Bouchard, Claude; Caulfield, W. L. Mark; Chambers, John C.; Curhan, Gary; Cusi, Daniele; Eriksson, Johan; Ferrucci, Luigi; van Gilst, Wiek H.; Glorioso, Nicola; de Graaf, Jacqueline; Groop, Leif; Gyllensten, Ulf; Hsueh, Wen-Chi; Hu, Frank B.; Huikuri, Heikki V.; Hunter, David J.; Iribarren, Carlos; Isomaa, Bo; Jarvelin, Marjo-Riitta; Jula, Antti; Kahonen, Mika; Kiemeney, Lambertus A.; van der Klauw, Melanie M.; Kooner, Jaspal S.; Kraft, Peter; Iacoviello, Licia; Lehtimaki, Terho; Lokki, Marja-Liisa L.; Mitchell, Braxton D.; Navis, Gerjan; Nieminen, Markku S.; Ohlsson, Claes; Poulter, Neil R.; Qi, Lu; Raitakari, Olli T.; Rimm, Eric B.; Rioux, John D.; Rizzi, Federica; Rudan, Igor; Salomaa, Veikko; Sever, Peter S.; Shields, Denis C.; Shuldiner, Alan R.; Sinisalo, Juha; Stanton, Alice V.; Stolk, Ronald P.; Strachan, David P.; Tardif, Jean-Claude; Thorsteinsdottir, Unnur; Tuomilehto, Jaako; van Veldhuisen, Dirk J.; Virtamo, Jarmo; Viikari, Jorma; Vollenweider, Peter; Waeber, Gerard; Widen, Elisabeth; Cho, Yoon Shin; Olsen, Jesper V.; Visscher, Peter M.; Willer, Cristen; Franke, Lude; Erdmann, Jeanette; Thompson, John R.; Pfeufer, Arne; Sotoodehnia, Nona; Newton-Cheh, Christopher; Ellinor, Patrick T.; Stricker, Bruno H. Ch; Metspalu, Andres; Perola, Markus; Beckmann, Jacques S.; Smith, George Davey; Stefansson, Kari; Wareham, Nicholas J.; Munroe, Patricia B.; Sibon, Ody C. M.; Milan, David J.; Snieder, Harold; Samani, Nilesh J.; Loos, Ruth J. F.

In: Nature Genetics, Vol. 45, No. 6, 2013, p. 621-631.

Research output: Contribution to journalArticle

Harvard

den Hoed, M, Eijgelsheim, M, Esko, T, Brundel, BJJM, Peal, DS, Evans, DM, Nolte, IM, Segre, AV, Holm, H, Handsaker, RE, Westra, H-J, Johnson, T, Isaacs, A, Yang, J, Lundby, A, Zhao, JH, Kim, YJ, Go, MJ, Almgren, P, Bochud, M, Boucher, G, Cornelis, MC, Gudbjartsson, D, Hadley, D, van der Harst, P, Hayward, C, den Heijer, M, Igl, W, Jackson, AU, Kutalik, Z, Luan, J, Kemp, JP, Kristiansson, K, Ladenvall, C, Lorentzon, M, Montasser, ME, Njajou, OT, O'Reilly, PF, Padmanabhan, S, Pourcain, BS, Rankinen, T, Salo, P, Tanaka, T, Timpson, NJ, Vitart, V, Waite, L, Wheeler, W, Zhang, W, Draisma, HHM, Feitosa, MF, Kerr, KF, Lind, PA, Mihailov, E, Onland-Moret, NC, Song, C, Weedon, MN, Xie, W, Yengo, L, Absher, D, Albert, CM, Alonso, A, Arking, DE, de Bakker, PIW, Balkau, B, Barlassina, C, Benaglio, P, Bis, JC, Bouatia-Naji, N, Brage, S, Chanock, SJ, Chines, PS, Chung, M, Darbar, D, Dina, C, Doerr, M, Elliott, P, Felix, SB, Fischer, K, Fuchsberger, C, de Geus, EJC, Goyette, P, Gudnason, V, Harris, TB, Hartikainen, A-L, Havulinna, AS, Heckbert, SR, Hicks, AA, Hofman, A, Holewijn, S, Hoogstra-Berends, F, Hottenga, J-J, Jensen, MK, Johansson, A, Junttila, J, Kaeaeb, S, Kanon, B, Ketkar, S, Khaw, K-T, Knowles, JW, Kooner, AS, Kors, JA, Kumari, M, Milani, L, Laiho, P, Lakatta, EG, Langenberg, C, Leusink, M, Liu, Y, Luben, RN, Lunetta, KL, Lynch, SN, Markus, MRP, Marques-Vidal, P, Leach, IM, McArdle, WL, McCarroll, SA, Medland, SE, Miller, KA, Montgomery, GW, Morrison, AC, Mueller-Nurasyid, M, Navarro, P, Nelis, M, O'Connell, JR, O'Donnell, CJ, Ong, KK, Newman, AB, Peters, A, Polasek, O, Pouta, A, Pramstaller, PP, Psaty, BM, Rao, DC, Ring, SM, Rossin, EJ, Rudan, D, Sanna, S, Scott, RA, Sehmi, JS, Sharp, S, Shin, JT, Singleton, AB, Smith, AV, Soranzo, N, Spector, TD, Stewart, C, Stringham, HM, Tarasov, KV, Uitterlinden, AG, Vandenput, L, Hwang, S-J, Whitfield, JB, Wijmenga, C, Wild, SH, Willemsen, G, Wilson, JF, Witteman, JCM, Wong, A, Wong, Q, Jamshidi, Y, Zitting, P, Boer, JMA, Boomsma, DI, Borecki, IB, van Duijn, CM, Ekelund, U, Forouhi, NG, Froguel, P, Hingorani, A, Ingelsson, E, Kivimaki, M, Kronmal, RA, Kuh, D, Lind, L, Martin, NG, Oostra, BA, Pedersen, NL, Quertermous, T, Rotter, JI, van der Schouw, YT, Verschuren, WMM, Walker, M, Albanes, D, Arnar, DO, Assimes, TL, Bandinelli, S, Boehnke, M, de Boer, RA, Bouchard, C, Caulfield, WLM, Chambers, JC, Curhan, G, Cusi, D, Eriksson, J, Ferrucci, L, van Gilst, WH, Glorioso, N, de Graaf, J, Groop, L, Gyllensten, U, Hsueh, W-C, Hu, FB, Huikuri, HV, Hunter, DJ, Iribarren, C, Isomaa, B, Jarvelin, M-R, Jula, A, Kahonen, M, Kiemeney, LA, van der Klauw, MM, Kooner, JS, Kraft, P, Iacoviello, L, Lehtimaki, T, Lokki, M-LL, Mitchell, BD, Navis, G, Nieminen, MS, Ohlsson, C, Poulter, NR, Qi, L, Raitakari, OT, Rimm, EB, Rioux, JD, Rizzi, F, Rudan, I, Salomaa, V, Sever, PS, Shields, DC, Shuldiner, AR, Sinisalo, J, Stanton, AV, Stolk, RP, Strachan, DP, Tardif, J-C, Thorsteinsdottir, U, Tuomilehto, J, van Veldhuisen, DJ, Virtamo, J, Viikari, J, Vollenweider, P, Waeber, G, Widen, E, Cho, YS, Olsen, JV, Visscher, PM, Willer, C, Franke, L, Erdmann, J, Thompson, JR, Pfeufer, A, Sotoodehnia, N, Newton-Cheh, C, Ellinor, PT, Stricker, BHC, Metspalu, A, Perola, M, Beckmann, JS, Smith, GD, Stefansson, K, Wareham, NJ, Munroe, PB, Sibon, OCM, Milan, DJ, Snieder, H, Samani, NJ & Loos, RJF 2013, 'Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders', Nature Genetics, vol. 45, no. 6, pp. 621-631. https://doi.org/10.1038/ng.2610

APA

den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., Nolte, I. M., Segre, A. V., Holm, H., Handsaker, R. E., Westra, H-J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., ... Loos, R. J. F. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45(6), 621-631. https://doi.org/10.1038/ng.2610

CBE

den Hoed M, Eijgelsheim M, Esko T, Brundel BJJM, Peal DS, Evans DM, Nolte IM, Segre AV, Holm H, Handsaker RE, Westra H-J, Johnson T, Isaacs A, Yang J, Lundby A, Zhao JH, Kim YJ, Go MJ, Almgren P, Bochud M, Boucher G, Cornelis MC, Gudbjartsson D, Hadley D, van der Harst P, Hayward C, den Heijer M, Igl W, Jackson AU, Kutalik Z, Luan J, Kemp JP, Kristiansson K, Ladenvall C, Lorentzon M, Montasser ME, Njajou OT, O'Reilly PF, Padmanabhan S, Pourcain BS, Rankinen T, Salo P, Tanaka T, Timpson NJ, Vitart V, Waite L, Wheeler W, Zhang W, Draisma HHM, Feitosa MF, Kerr KF, Lind PA, Mihailov E, Onland-Moret NC, Song C, Weedon MN, Xie W, Yengo L, Absher D, Albert CM, Alonso A, Arking DE, de Bakker PIW, Balkau B, Barlassina C, Benaglio P, Bis JC, Bouatia-Naji N, Brage S, Chanock SJ, Chines PS, Chung M, Darbar D, Dina C, Doerr M, Elliott P, Felix SB, Fischer K, Fuchsberger C, de Geus EJC, Goyette P, Gudnason V, Harris TB, Hartikainen A-L, Havulinna AS, Heckbert SR, Hicks AA, Hofman A, Holewijn S, Hoogstra-Berends F, Hottenga J-J, Jensen MK, Johansson A, Junttila J, Kaeaeb S, Kanon B, Ketkar S, Khaw K-T, Knowles JW, Kooner AS, Kors JA, Kumari M, Milani L, Laiho P, Lakatta EG, Langenberg C, Leusink M, Liu Y, Luben RN, Lunetta KL, Lynch SN, Markus MRP, Marques-Vidal P, Leach IM, McArdle WL, McCarroll SA, Medland SE, Miller KA, Montgomery GW, Morrison AC, Mueller-Nurasyid M, Navarro P, Nelis M, O'Connell JR, O'Donnell CJ, Ong KK, Newman AB, Peters A, Polasek O, Pouta A, Pramstaller PP, Psaty BM, Rao DC, Ring SM, Rossin EJ, Rudan D, Sanna S, Scott RA, Sehmi JS, Sharp S, Shin JT, Singleton AB, Smith AV, Soranzo N, Spector TD, Stewart C, Stringham HM, Tarasov KV, Uitterlinden AG, Vandenput L, Hwang S-J, Whitfield JB, Wijmenga C, Wild SH, Willemsen G, Wilson JF, Witteman JCM, Wong A, Wong Q, Jamshidi Y, Zitting P, Boer JMA, Boomsma DI, Borecki IB, van Duijn CM, Ekelund U, Forouhi NG, Froguel P, Hingorani A, Ingelsson E, Kivimaki M, Kronmal RA, Kuh D, Lind L, Martin NG, Oostra BA, Pedersen NL, Quertermous T, Rotter JI, van der Schouw YT, Verschuren WMM, Walker M, Albanes D, Arnar DO, Assimes TL, Bandinelli S, Boehnke M, de Boer RA, Bouchard C, Caulfield WLM, Chambers JC, Curhan G, Cusi D, Eriksson J, Ferrucci L, van Gilst WH, Glorioso N, de Graaf J, Groop L, Gyllensten U, Hsueh W-C, Hu FB, Huikuri HV, Hunter DJ, Iribarren C, Isomaa B, Jarvelin M-R, Jula A, Kahonen M, Kiemeney LA, van der Klauw MM, Kooner JS, Kraft P, Iacoviello L, Lehtimaki T, Lokki M-LL, Mitchell BD, Navis G, Nieminen MS, Ohlsson C, Poulter NR, Qi L, Raitakari OT, Rimm EB, Rioux JD, Rizzi F, Rudan I, Salomaa V, Sever PS, Shields DC, Shuldiner AR, Sinisalo J, Stanton AV, Stolk RP, Strachan DP, Tardif J-C, Thorsteinsdottir U, Tuomilehto J, van Veldhuisen DJ, Virtamo J, Viikari J, Vollenweider P, Waeber G, Widen E, Cho YS, Olsen JV, Visscher PM, Willer C, Franke L, Erdmann J, Thompson JR, Pfeufer A, Sotoodehnia N, Newton-Cheh C, Ellinor PT, Stricker BHC, Metspalu A, Perola M, Beckmann JS, Smith GD, Stefansson K, Wareham NJ, Munroe PB, Sibon OCM, Milan DJ, Snieder H, Samani NJ, Loos RJF. 2013. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics. 45(6):621-631. https://doi.org/10.1038/ng.2610

MLA

Vancouver

Author

den Hoed, Marcel ; Eijgelsheim, Mark ; Esko, Tonu ; Brundel, Bianca J. J. M. ; Peal, David S. ; Evans, David M. ; Nolte, Ilja M. ; Segre, Ayellet V. ; Holm, Hilma ; Handsaker, Robert E. ; Westra, Harm-Jan ; Johnson, Toby ; Isaacs, Aaron ; Yang, Jian ; Lundby, Alicia ; Zhao, Jing Hua ; Kim, Young Jin ; Go, Min Jin ; Almgren, Peter ; Bochud, Murielle ; Boucher, Gabrielle ; Cornelis, Marilyn C. ; Gudbjartsson, Daniel ; Hadley, David ; van der Harst, Pim ; Hayward, Caroline ; den Heijer, Martin ; Igl, Wilmar ; Jackson, Anne U. ; Kutalik, Zoltan ; Luan, Jian'an ; Kemp, John P. ; Kristiansson, Kati ; Ladenvall, Claes ; Lorentzon, Mattias ; Montasser, May E. ; Njajou, Omer T. ; O'Reilly, Paul F. ; Padmanabhan, Sandosh ; Pourcain, Beate St. ; Rankinen, Tuomo ; Salo, Perttu ; Tanaka, Toshiko ; Timpson, Nicholas J. ; Vitart, Veronique ; Waite, Lindsay ; Wheeler, William ; Zhang, Weihua ; Draisma, Harmen H. M. ; Feitosa, Mary F. ; Kerr, Kathleen F. ; Lind, Penelope A. ; Mihailov, Evelin ; Onland-Moret, N. Charlotte ; Song, Ci ; Weedon, Michael N. ; Xie, Weijia ; Yengo, Loic ; Absher, Devin ; Albert, Christine M. ; Alonso, Alvaro ; Arking, Dan E. ; de Bakker, Paul I. W. ; Balkau, Beverley ; Barlassina, Cristina ; Benaglio, Paola ; Bis, Joshua C. ; Bouatia-Naji, Nabila ; Brage, Soren ; Chanock, Stephen J. ; Chines, Peter S. ; Chung, Mina ; Darbar, Dawood ; Dina, Christian ; Doerr, Marcus ; Elliott, Paul ; Felix, Stephan B. ; Fischer, Krista ; Fuchsberger, Christian ; de Geus, Eco J. C. ; Goyette, Philippe ; Gudnason, Vilmundur ; Harris, Tamara B. ; Hartikainen, Anna-Liisa ; Havulinna, Aki S. ; Heckbert, Susan R. ; Hicks, Andrew A. ; Hofman, Albert ; Holewijn, Suzanne ; Hoogstra-Berends, Femke ; Hottenga, Jouke-Jan ; Jensen, Majken K. ; Johansson, Asa ; Junttila, Juhani ; Kaeaeb, Stefan ; Kanon, Bart ; Ketkar, Shamika ; Khaw, Kay-Tee ; Knowles, Joshua W. ; Kooner, Angrad S. ; Kors, Jan A. ; Kumari, Meena ; Milani, Lili ; Laiho, Paeivi ; Lakatta, Edward G. ; Langenberg, Claudia ; Leusink, Maarten ; Liu, Yongmei ; Luben, Robert N. ; Lunetta, Kathryn L. ; Lynch, Stacey N. ; Markus, Marcello R. P. ; Marques-Vidal, Pedro ; Leach, Irene Mateo ; McArdle, Wendy L. ; McCarroll, Steven A. ; Medland, Sarah E. ; Miller, Kathryn A. ; Montgomery, Grant W. ; Morrison, Alanna C. ; Mueller-Nurasyid, Martina ; Navarro, Pau ; Nelis, Mari ; O'Connell, Jeffrey R. ; O'Donnell, Christopher J. ; Ong, Ken K. ; Newman, Anne B. ; Peters, Annette ; Polasek, Ozren ; Pouta, Anneli ; Pramstaller, Peter P. ; Psaty, Bruce M. ; Rao, Dabeeru C. ; Ring, Susan M. ; Rossin, Elizabeth J. ; Rudan, Diana ; Sanna, Serena ; Scott, Robert A. ; Sehmi, Jaban S. ; Sharp, Stephen ; Shin, Jordan T. ; Singleton, Andrew B. ; Smith, Albert V. ; Soranzo, Nicole ; Spector, Tim D. ; Stewart, Chip ; Stringham, Heather M. ; Tarasov, Kirill V. ; Uitterlinden, Andre G. ; Vandenput, Liesbeth ; Hwang, Shih-Jen ; Whitfield, John B. ; Wijmenga, Cisca ; Wild, Sarah H. ; Willemsen, Gonneke ; Wilson, James F. ; Witteman, Jacqueline C. M. ; Wong, Andrew ; Wong, Quenna ; Jamshidi, Yalda ; Zitting, Paavo ; Boer, Jolanda M. A. ; Boomsma, Dorret I. ; Borecki, Ingrid B. ; van Duijn, Cornelia M. ; Ekelund, Ulf ; Forouhi, Nita G. ; Froguel, Philippe ; Hingorani, Aroon ; Ingelsson, Erik ; Kivimaki, Mika ; Kronmal, Richard A. ; Kuh, Diana ; Lind, Lars ; Martin, Nicholas G. ; Oostra, Ben A. ; Pedersen, Nancy L. ; Quertermous, Thomas ; Rotter, Jerome I. ; van der Schouw, Yvonne T. ; Verschuren, W. M. Monique ; Walker, Mark ; Albanes, Demetrius ; Arnar, David O. ; Assimes, Themistocles L. ; Bandinelli, Stefania ; Boehnke, Michael ; de Boer, Rudolf A. ; Bouchard, Claude ; Caulfield, W. L. Mark ; Chambers, John C. ; Curhan, Gary ; Cusi, Daniele ; Eriksson, Johan ; Ferrucci, Luigi ; van Gilst, Wiek H. ; Glorioso, Nicola ; de Graaf, Jacqueline ; Groop, Leif ; Gyllensten, Ulf ; Hsueh, Wen-Chi ; Hu, Frank B. ; Huikuri, Heikki V. ; Hunter, David J. ; Iribarren, Carlos ; Isomaa, Bo ; Jarvelin, Marjo-Riitta ; Jula, Antti ; Kahonen, Mika ; Kiemeney, Lambertus A. ; van der Klauw, Melanie M. ; Kooner, Jaspal S. ; Kraft, Peter ; Iacoviello, Licia ; Lehtimaki, Terho ; Lokki, Marja-Liisa L. ; Mitchell, Braxton D. ; Navis, Gerjan ; Nieminen, Markku S. ; Ohlsson, Claes ; Poulter, Neil R. ; Qi, Lu ; Raitakari, Olli T. ; Rimm, Eric B. ; Rioux, John D. ; Rizzi, Federica ; Rudan, Igor ; Salomaa, Veikko ; Sever, Peter S. ; Shields, Denis C. ; Shuldiner, Alan R. ; Sinisalo, Juha ; Stanton, Alice V. ; Stolk, Ronald P. ; Strachan, David P. ; Tardif, Jean-Claude ; Thorsteinsdottir, Unnur ; Tuomilehto, Jaako ; van Veldhuisen, Dirk J. ; Virtamo, Jarmo ; Viikari, Jorma ; Vollenweider, Peter ; Waeber, Gerard ; Widen, Elisabeth ; Cho, Yoon Shin ; Olsen, Jesper V. ; Visscher, Peter M. ; Willer, Cristen ; Franke, Lude ; Erdmann, Jeanette ; Thompson, John R. ; Pfeufer, Arne ; Sotoodehnia, Nona ; Newton-Cheh, Christopher ; Ellinor, Patrick T. ; Stricker, Bruno H. Ch ; Metspalu, Andres ; Perola, Markus ; Beckmann, Jacques S. ; Smith, George Davey ; Stefansson, Kari ; Wareham, Nicholas J. ; Munroe, Patricia B. ; Sibon, Ody C. M. ; Milan, David J. ; Snieder, Harold ; Samani, Nilesh J. ; Loos, Ruth J. F. / Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. In: Nature Genetics. 2013 ; Vol. 45, No. 6. pp. 621-631.

RIS

TY - JOUR

T1 - Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

AU - den Hoed, Marcel

AU - Eijgelsheim, Mark

AU - Esko, Tonu

AU - Brundel, Bianca J. J. M.

AU - Peal, David S.

AU - Evans, David M.

AU - Nolte, Ilja M.

AU - Segre, Ayellet V.

AU - Holm, Hilma

AU - Handsaker, Robert E.

AU - Westra, Harm-Jan

AU - Johnson, Toby

AU - Isaacs, Aaron

AU - Yang, Jian

AU - Lundby, Alicia

AU - Zhao, Jing Hua

AU - Kim, Young Jin

AU - Go, Min Jin

AU - Almgren, Peter

AU - Bochud, Murielle

AU - Boucher, Gabrielle

AU - Cornelis, Marilyn C.

AU - Gudbjartsson, Daniel

AU - Hadley, David

AU - van der Harst, Pim

AU - Hayward, Caroline

AU - den Heijer, Martin

AU - Igl, Wilmar

AU - Jackson, Anne U.

AU - Kutalik, Zoltan

AU - Luan, Jian'an

AU - Kemp, John P.

AU - Kristiansson, Kati

AU - Ladenvall, Claes

AU - Lorentzon, Mattias

AU - Montasser, May E.

AU - Njajou, Omer T.

AU - O'Reilly, Paul F.

AU - Padmanabhan, Sandosh

AU - Pourcain, Beate St.

AU - Rankinen, Tuomo

AU - Salo, Perttu

AU - Tanaka, Toshiko

AU - Timpson, Nicholas J.

AU - Vitart, Veronique

AU - Waite, Lindsay

AU - Wheeler, William

AU - Zhang, Weihua

AU - Draisma, Harmen H. M.

AU - Feitosa, Mary F.

AU - Kerr, Kathleen F.

AU - Lind, Penelope A.

AU - Mihailov, Evelin

AU - Onland-Moret, N. Charlotte

AU - Song, Ci

AU - Weedon, Michael N.

AU - Xie, Weijia

AU - Yengo, Loic

AU - Absher, Devin

AU - Albert, Christine M.

AU - Alonso, Alvaro

AU - Arking, Dan E.

AU - de Bakker, Paul I. W.

AU - Balkau, Beverley

AU - Barlassina, Cristina

AU - Benaglio, Paola

AU - Bis, Joshua C.

AU - Bouatia-Naji, Nabila

AU - Brage, Soren

AU - Chanock, Stephen J.

AU - Chines, Peter S.

AU - Chung, Mina

AU - Darbar, Dawood

AU - Dina, Christian

AU - Doerr, Marcus

AU - Elliott, Paul

AU - Felix, Stephan B.

AU - Fischer, Krista

AU - Fuchsberger, Christian

AU - de Geus, Eco J. C.

AU - Goyette, Philippe

AU - Gudnason, Vilmundur

AU - Harris, Tamara B.

AU - Hartikainen, Anna-Liisa

AU - Havulinna, Aki S.

AU - Heckbert, Susan R.

AU - Hicks, Andrew A.

AU - Hofman, Albert

AU - Holewijn, Suzanne

AU - Hoogstra-Berends, Femke

AU - Hottenga, Jouke-Jan

AU - Jensen, Majken K.

AU - Johansson, Asa

AU - Junttila, Juhani

AU - Kaeaeb, Stefan

AU - Kanon, Bart

AU - Ketkar, Shamika

AU - Khaw, Kay-Tee

AU - Knowles, Joshua W.

AU - Kooner, Angrad S.

AU - Kors, Jan A.

AU - Kumari, Meena

AU - Milani, Lili

AU - Laiho, Paeivi

AU - Lakatta, Edward G.

AU - Langenberg, Claudia

AU - Leusink, Maarten

AU - Liu, Yongmei

AU - Luben, Robert N.

AU - Lunetta, Kathryn L.

AU - Lynch, Stacey N.

AU - Markus, Marcello R. P.

AU - Marques-Vidal, Pedro

AU - Leach, Irene Mateo

AU - McArdle, Wendy L.

AU - McCarroll, Steven A.

AU - Medland, Sarah E.

AU - Miller, Kathryn A.

AU - Montgomery, Grant W.

AU - Morrison, Alanna C.

AU - Mueller-Nurasyid, Martina

AU - Navarro, Pau

AU - Nelis, Mari

AU - O'Connell, Jeffrey R.

AU - O'Donnell, Christopher J.

AU - Ong, Ken K.

AU - Newman, Anne B.

AU - Peters, Annette

AU - Polasek, Ozren

AU - Pouta, Anneli

AU - Pramstaller, Peter P.

AU - Psaty, Bruce M.

AU - Rao, Dabeeru C.

AU - Ring, Susan M.

AU - Rossin, Elizabeth J.

AU - Rudan, Diana

AU - Sanna, Serena

AU - Scott, Robert A.

AU - Sehmi, Jaban S.

AU - Sharp, Stephen

AU - Shin, Jordan T.

AU - Singleton, Andrew B.

AU - Smith, Albert V.

AU - Soranzo, Nicole

AU - Spector, Tim D.

AU - Stewart, Chip

AU - Stringham, Heather M.

AU - Tarasov, Kirill V.

AU - Uitterlinden, Andre G.

AU - Vandenput, Liesbeth

AU - Hwang, Shih-Jen

AU - Whitfield, John B.

AU - Wijmenga, Cisca

AU - Wild, Sarah H.

AU - Willemsen, Gonneke

AU - Wilson, James F.

AU - Witteman, Jacqueline C. M.

AU - Wong, Andrew

AU - Wong, Quenna

AU - Jamshidi, Yalda

AU - Zitting, Paavo

AU - Boer, Jolanda M. A.

AU - Boomsma, Dorret I.

AU - Borecki, Ingrid B.

AU - van Duijn, Cornelia M.

AU - Ekelund, Ulf

AU - Forouhi, Nita G.

AU - Froguel, Philippe

AU - Hingorani, Aroon

AU - Ingelsson, Erik

AU - Kivimaki, Mika

AU - Kronmal, Richard A.

AU - Kuh, Diana

AU - Lind, Lars

AU - Martin, Nicholas G.

AU - Oostra, Ben A.

AU - Pedersen, Nancy L.

AU - Quertermous, Thomas

AU - Rotter, Jerome I.

AU - van der Schouw, Yvonne T.

AU - Verschuren, W. M. Monique

AU - Walker, Mark

AU - Albanes, Demetrius

AU - Arnar, David O.

AU - Assimes, Themistocles L.

AU - Bandinelli, Stefania

AU - Boehnke, Michael

AU - de Boer, Rudolf A.

AU - Bouchard, Claude

AU - Caulfield, W. L. Mark

AU - Chambers, John C.

AU - Curhan, Gary

AU - Cusi, Daniele

AU - Eriksson, Johan

AU - Ferrucci, Luigi

AU - van Gilst, Wiek H.

AU - Glorioso, Nicola

AU - de Graaf, Jacqueline

AU - Groop, Leif

AU - Gyllensten, Ulf

AU - Hsueh, Wen-Chi

AU - Hu, Frank B.

AU - Huikuri, Heikki V.

AU - Hunter, David J.

AU - Iribarren, Carlos

AU - Isomaa, Bo

AU - Jarvelin, Marjo-Riitta

AU - Jula, Antti

AU - Kahonen, Mika

AU - Kiemeney, Lambertus A.

AU - van der Klauw, Melanie M.

AU - Kooner, Jaspal S.

AU - Kraft, Peter

AU - Iacoviello, Licia

AU - Lehtimaki, Terho

AU - Lokki, Marja-Liisa L.

AU - Mitchell, Braxton D.

AU - Navis, Gerjan

AU - Nieminen, Markku S.

AU - Ohlsson, Claes

AU - Poulter, Neil R.

AU - Qi, Lu

AU - Raitakari, Olli T.

AU - Rimm, Eric B.

AU - Rioux, John D.

AU - Rizzi, Federica

AU - Rudan, Igor

AU - Salomaa, Veikko

AU - Sever, Peter S.

AU - Shields, Denis C.

AU - Shuldiner, Alan R.

AU - Sinisalo, Juha

AU - Stanton, Alice V.

AU - Stolk, Ronald P.

AU - Strachan, David P.

AU - Tardif, Jean-Claude

AU - Thorsteinsdottir, Unnur

AU - Tuomilehto, Jaako

AU - van Veldhuisen, Dirk J.

AU - Virtamo, Jarmo

AU - Viikari, Jorma

AU - Vollenweider, Peter

AU - Waeber, Gerard

AU - Widen, Elisabeth

AU - Cho, Yoon Shin

AU - Olsen, Jesper V.

AU - Visscher, Peter M.

AU - Willer, Cristen

AU - Franke, Lude

AU - Erdmann, Jeanette

AU - Thompson, John R.

AU - Pfeufer, Arne

AU - Sotoodehnia, Nona

AU - Newton-Cheh, Christopher

AU - Ellinor, Patrick T.

AU - Stricker, Bruno H. Ch

AU - Metspalu, Andres

AU - Perola, Markus

AU - Beckmann, Jacques S.

AU - Smith, George Davey

AU - Stefansson, Kari

AU - Wareham, Nicholas J.

AU - Munroe, Patricia B.

AU - Sibon, Ody C. M.

AU - Milan, David J.

AU - Snieder, Harold

AU - Samani, Nilesh J.

AU - Loos, Ruth J. F.

PY - 2013

Y1 - 2013

N2 - Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.

AB - Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.

U2 - 10.1038/ng.2610

DO - 10.1038/ng.2610

M3 - Article

C2 - 23583979

VL - 45

SP - 621

EP - 631

JO - Nature Genetics

JF - Nature Genetics

SN - 1546-1718

IS - 6

ER -