Identification of serum biomarker signatures associated with pancreatic cancer

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer is an aggressive disease with poor prognosis, due, in part, to the lack of disease-specific biomarkers that could afford early and accurate diagnosis. With a recombinant antibody microarray platform, targeting mainly immunoregulatory proteins, we screened sera from 148 patients with pancreatic cancer, chronic pancreatitis, autoimmune pancreatitis (AIP), and healthy controls (N). Serum biomarker signatures were derived from training cohorts and the predictive power was evaluated using independent test cohorts. The results identified serum portraits distinguishing pancreatic cancer from N [receiver operating characteristics area under the curve (AUC) of 0.95], chronic pancreatitis (0.86), and AIP (0.99). Importantly, a 25-serum biomarker signature discriminating pancreatic cancer from the combined group of N, chronic pancreatitis, and AIP was determined. This signature exhibited a high diagnostic potential (AUC of 0.88). In summary, we present the first prevalidated, multiplexed serum biomarker signature for diagnosis of pancreatic cancer that may improve diagnosis and prevention in premalignant diseases and in screening of high-risk individuals.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • Pancreatic Neoplasms/*blood, Middle Aged, Humans, Pancreatic Ductal/*blood, Carcinoma, Biological Markers/blood, 80 and over, Aged, Adolescent, Adult, Pancreatitis/diagnosis, Pancreatitis, Chronic/blood, Tumor Markers, Biological/*blood
Original languageEnglish
Pages (from-to)2481-90
JournalCancer Research
Volume72
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

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