IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies

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title = "IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies",
abstract = "Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G > C (rs1800795) and -573G > C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on > 20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G > C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9{\%}. No evidence for association was found between IL6 -573G > C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.",
author = "Cornelia Huth and Heid, {Iris M.} and Caren Vollmert and Christian Gieger and Harald Grallert and Wolford, {Johanna K.} and Birgit Langer and Barbara Thorand and Norman Klopp and Hamid, {Yasmin H.} and Oluf Pedersen and Torben Hansen and Valeriya Lyssenko and Leif Groop and Christa Meisinger and Angela Doring and Hannelore Lowel and Wolfgang Lieb and Christian Hengstenberg and Wolfgang Rathmann and Stephan Martin and Stephens, {Jeffrey W.} and Helen Ireland and Hugh Mather and Miller, {George J.} and Stringham, {Heather M.} and Michael Boehnke and Jaakko Tuomilehto and Heiner Boeing and Matthias Mohlig and Joachim Spranger and Andreas Pfeiffer and Ingrid Wernstedt and Anders Niklason and Abel Lopez-Bermejo and Jose-Manuel Fernandez-Real and Hanson, {Robert L.} and Luis Gallart and Joan Vendrell and Anastasia Tsiavou and Erifili Hatziagelaki and Humphries, {Steve E.} and Wichmann, {H. -Erich} and Christian Herder and Thomas Illig",
year = "2006",
doi = "10.2337/db06-0600",
language = "English",
volume = "55",
pages = "2915--2921",
journal = "Diabetes",
issn = "1939-327X",
publisher = "American Diabetes Association Inc.",
number = "10",