IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies

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IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies. / Huth, Cornelia; Heid, Iris M.; Vollmert, Caren; Gieger, Christian; Grallert, Harald; Wolford, Johanna K.; Langer, Birgit; Thorand, Barbara; Klopp, Norman; Hamid, Yasmin H.; Pedersen, Oluf; Hansen, Torben; Lyssenko, Valeriya; Groop, Leif; Meisinger, Christa; Doring, Angela; Lowel, Hannelore; Lieb, Wolfgang; Hengstenberg, Christian; Rathmann, Wolfgang; Martin, Stephan; Stephens, Jeffrey W.; Ireland, Helen; Mather, Hugh; Miller, George J.; Stringham, Heather M.; Boehnke, Michael; Tuomilehto, Jaakko; Boeing, Heiner; Mohlig, Matthias; Spranger, Joachim; Pfeiffer, Andreas; Wernstedt, Ingrid; Niklason, Anders; Lopez-Bermejo, Abel; Fernandez-Real, Jose-Manuel; Hanson, Robert L.; Gallart, Luis; Vendrell, Joan; Tsiavou, Anastasia; Hatziagelaki, Erifili; Humphries, Steve E.; Wichmann, H. -Erich; Herder, Christian; Illig, Thomas.

In: Diabetes, Vol. 55, No. 10, 2006, p. 2915-2921.

Research output: Contribution to journalArticle

Harvard

Huth, C, Heid, IM, Vollmert, C, Gieger, C, Grallert, H, Wolford, JK, Langer, B, Thorand, B, Klopp, N, Hamid, YH, Pedersen, O, Hansen, T, Lyssenko, V, Groop, L, Meisinger, C, Doring, A, Lowel, H, Lieb, W, Hengstenberg, C, Rathmann, W, Martin, S, Stephens, JW, Ireland, H, Mather, H, Miller, GJ, Stringham, HM, Boehnke, M, Tuomilehto, J, Boeing, H, Mohlig, M, Spranger, J, Pfeiffer, A, Wernstedt, I, Niklason, A, Lopez-Bermejo, A, Fernandez-Real, J-M, Hanson, RL, Gallart, L, Vendrell, J, Tsiavou, A, Hatziagelaki, E, Humphries, SE, Wichmann, H-E, Herder, C & Illig, T 2006, 'IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies', Diabetes, vol. 55, no. 10, pp. 2915-2921. https://doi.org/10.2337/db06-0600

APA

Huth, C., Heid, I. M., Vollmert, C., Gieger, C., Grallert, H., Wolford, J. K., ... Illig, T. (2006). IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies. Diabetes, 55(10), 2915-2921. https://doi.org/10.2337/db06-0600

CBE

Huth C, Heid IM, Vollmert C, Gieger C, Grallert H, Wolford JK, Langer B, Thorand B, Klopp N, Hamid YH, Pedersen O, Hansen T, Lyssenko V, Groop L, Meisinger C, Doring A, Lowel H, Lieb W, Hengstenberg C, Rathmann W, Martin S, Stephens JW, Ireland H, Mather H, Miller GJ, Stringham HM, Boehnke M, Tuomilehto J, Boeing H, Mohlig M, Spranger J, Pfeiffer A, Wernstedt I, Niklason A, Lopez-Bermejo A, Fernandez-Real J-M, Hanson RL, Gallart L, Vendrell J, Tsiavou A, Hatziagelaki E, Humphries SE, Wichmann H-E, Herder C, Illig T. 2006. IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies. Diabetes. 55(10):2915-2921. https://doi.org/10.2337/db06-0600

MLA

Vancouver

Author

Huth, Cornelia ; Heid, Iris M. ; Vollmert, Caren ; Gieger, Christian ; Grallert, Harald ; Wolford, Johanna K. ; Langer, Birgit ; Thorand, Barbara ; Klopp, Norman ; Hamid, Yasmin H. ; Pedersen, Oluf ; Hansen, Torben ; Lyssenko, Valeriya ; Groop, Leif ; Meisinger, Christa ; Doring, Angela ; Lowel, Hannelore ; Lieb, Wolfgang ; Hengstenberg, Christian ; Rathmann, Wolfgang ; Martin, Stephan ; Stephens, Jeffrey W. ; Ireland, Helen ; Mather, Hugh ; Miller, George J. ; Stringham, Heather M. ; Boehnke, Michael ; Tuomilehto, Jaakko ; Boeing, Heiner ; Mohlig, Matthias ; Spranger, Joachim ; Pfeiffer, Andreas ; Wernstedt, Ingrid ; Niklason, Anders ; Lopez-Bermejo, Abel ; Fernandez-Real, Jose-Manuel ; Hanson, Robert L. ; Gallart, Luis ; Vendrell, Joan ; Tsiavou, Anastasia ; Hatziagelaki, Erifili ; Humphries, Steve E. ; Wichmann, H. -Erich ; Herder, Christian ; Illig, Thomas. / IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies. In: Diabetes. 2006 ; Vol. 55, No. 10. pp. 2915-2921.

RIS

TY - JOUR

T1 - IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies

AU - Huth, Cornelia

AU - Heid, Iris M.

AU - Vollmert, Caren

AU - Gieger, Christian

AU - Grallert, Harald

AU - Wolford, Johanna K.

AU - Langer, Birgit

AU - Thorand, Barbara

AU - Klopp, Norman

AU - Hamid, Yasmin H.

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Lyssenko, Valeriya

AU - Groop, Leif

AU - Meisinger, Christa

AU - Doring, Angela

AU - Lowel, Hannelore

AU - Lieb, Wolfgang

AU - Hengstenberg, Christian

AU - Rathmann, Wolfgang

AU - Martin, Stephan

AU - Stephens, Jeffrey W.

AU - Ireland, Helen

AU - Mather, Hugh

AU - Miller, George J.

AU - Stringham, Heather M.

AU - Boehnke, Michael

AU - Tuomilehto, Jaakko

AU - Boeing, Heiner

AU - Mohlig, Matthias

AU - Spranger, Joachim

AU - Pfeiffer, Andreas

AU - Wernstedt, Ingrid

AU - Niklason, Anders

AU - Lopez-Bermejo, Abel

AU - Fernandez-Real, Jose-Manuel

AU - Hanson, Robert L.

AU - Gallart, Luis

AU - Vendrell, Joan

AU - Tsiavou, Anastasia

AU - Hatziagelaki, Erifili

AU - Humphries, Steve E.

AU - Wichmann, H. -Erich

AU - Herder, Christian

AU - Illig, Thomas

PY - 2006

Y1 - 2006

N2 - Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G > C (rs1800795) and -573G > C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on > 20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G > C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G > C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.

AB - Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G > C (rs1800795) and -573G > C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on > 20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G > C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G > C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.

U2 - 10.2337/db06-0600

DO - 10.2337/db06-0600

M3 - Article

VL - 55

SP - 2915

EP - 2921

JO - Diabetes

JF - Diabetes

SN - 1939-327X

IS - 10

ER -