Imidazo[1,2-a]pyridine derivatives as inhibitors of TNF-alpha expression in T cells

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title = "Imidazo[1,2-a]pyridine derivatives as inhibitors of TNF-alpha expression in T cells",
abstract = "Novel hexahydroimidazo[1,2-a]pyridines prepared by the addition of ethyl (1-benzylimidazolidin-2-ylidene)acetate (2) to the fungal metabolite podoscyphic acid (1a) and esters of 1a have been evaluated for their ability to inhibit the inducible TNF-α promoter activity in T cells. The methyl ester 3b is the most potent, inhibiting the TNF-α driven reporter gene expression in Jurkat T cells with an IC50-value of 2.0 μg/ml (3.6 μM). In addition, compound 3b inhibited the inducible TNF-α production in the myelomonocytic U937 cells with an IC50-value of 4.6 μM.",
keywords = "Semisynthesis, Podoscyphic acid, Inflammation, Promoter activity, TNF-α, Inhibitor",
author = "Jan Rether and Gerhard Erkel and Timm Anke and {Eriksson Bajtner}, Johan and Olov Sterner",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",
year = "2008",
doi = "10.1016/j.bmc.2007.10.074",
language = "English",
volume = "16",
pages = "1236--1241",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier",
number = "3",