Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases

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title = "Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases",
abstract = "Correct diagnosis of pulmonary tumors is essential for treatment decision and often relies on immunohistochemical markers. We stained tissue microarrays from resected primary lung cancer (n = 665) and pulmonary metastases (n = 425) for CK7, CK20, CDX2, CK5, p40, p63, TTF-1, napsin A, GATA3, and PAX8 to systematically assess the diagnostic value of these markers. Primary lung adenocarcinomas expressed TTF-1 in 90{\%} and napsin A in 84{\%} of the cases, whereas 10{\%} were positive for p63, 7{\%} for CDX2, 2{\%} for CK20, and 2{\%} for GATA3. Only 68{\%} of the lung adenocarcinomas were positive for CK7, TTF-1, and napsin A and negative for all other markers. Primary lung squamous cell carcinomas expressed CK5, p40, and p63 in 94{\%}-97{\%} of cases, whereas 44{\%} were positive for CK7, 20{\%} for GATA3, 7{\%} for CDX2, and 3{\%} for TTF-1. Rare cases expressed PAX8, CK20, or napsin A. Pulmonary metastases of colorectal cancer were positive for CK20 in 83{\%} and CDX2 in 99{\%} of the cases. Rare cases expressed CK7, p63, or PAX8, whereas 4{\%} expressed TTF-1. Pulmonary metastases of renal cell carcinomas were positive for PAX8 in 74{\%}, napsin A in 7{\%}, and CK7 in 7{\%} of the cases. Pulmonary metastases of breast cancer were positive for GATA3 in 93{\%} and CK7 in 78{\%} of the cases, whereas 15{\%} expressed CK5. Information on expression and patterns of immunohistochemical markers facilitates histopathological diagnostics. Evidently, unusual immune profiles occur and may lead to incorrect diagnosis.",
keywords = "CDX2, Cytokeratin, GATA3, Napsin A, Tissue microarray, TTF-1",
author = "Halla Vidarsdottir and Lena Tran and Bj{\"o}rn Nodin and Karin Jirstr{\"o}m and Maria Planck and Per J{\"o}nsson and Mattsson, {Johanna S.M.} and Johan Botling and Patrick Micke and Hans Brunnstr{\"o}m",
year = "2019",
doi = "10.1016/j.humpath.2018.10.009",
language = "English",
volume = "84",
pages = "221--230",
journal = "Human Pathology",
issn = "1532-8392",
publisher = "Elsevier",