Impact of age and comorbidity on risk stratification in idiopathic pulmonary arterial hypertension

Research output: Contribution to journalArticle

Abstract

Recent reports from worldwide pulmonary hypertension registries show a new demographic picture for patients with idiopathic pulmonary arterial hypertension (IPAH), with an increasing prevalence among the elderly. We aimed to investigate the effects of age and comorbidity on risk stratification and outcome of patients with incident IPAH. The study population (n=264) was categorised into four age groups: 18-45, 46-64, 65-74 and 75 years. Individual risk profiles were determined according to a risk assessment instrument, based on the European Society of Cardiology and the European Respiratory Society guidelines. The change in risk group from baseline to follow-up (median 5 months) and survival were compared across age groups. In the two youngest age groups, a significant number of patients improved (18-45 years, Z= −4.613, p<0.001; 46-64 years, Z= −2.125, p=0.034), but no significant improvement was found in the older patient groups. 5-year survival was highest in patients aged 18-45 years (88%), while the survival rates were 63%, 56% and 36% for patients in the groups 46-64, 65-74 and 75 years, respectively (p<0.001). Ischaemic heart disease and kidney dysfunction independently predicted survival. These findings highlight the importance of age and specific comorbidities as prognostic markers of outcome in addition to established risk assessment algorithms.

Details

Authors
  • Clara Hjalmarsson
  • Göran Rådegran
  • David Kylhammar
  • Bengt Rundqvist
  • Jonas Multing
  • Magnus D. Nisell
  • Barbro Kjellström
  • SveFPH
  • SPAHR
Organisations
External organisations
  • Sahlgrenska Academy
  • Sahlgrenska University Hospital
  • Skåne University Hospital
  • Linköping University
  • Karolinska Institutet
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy
Original languageEnglish
Article number1702310
JournalEuropean Respiratory Journal
Volume51
Issue number5
Publication statusPublished - 2018 May 1
Publication categoryResearch
Peer-reviewedYes