Impact of combinations of antineoplastic drugs on intestinal microflora in 9 patients with leukaemia.

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Abstract

The impact of antineoplastic drugs on the intestinal microflora was studied in 9 patients with acute leukaemia during chemotherapy and in 5 patients also during chemotherapy-induced neutropenia. Quantitative and qualitative microbiological analyses of faecal samples obtained before and during chemotherapy showed significantly increased counts of Bacteroides spp. in 3/9 patients and, during neutropenia, significantly increased counts of yeasts in 2/5 patients; however, the intestinal microflora was stable in most patients.

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  • Infectious Medicine
Original languageEnglish
Pages (from-to)17-21
JournalScandinavian Journal of Infectious Diseases
Volume34
Issue number1
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes