Impact of psychiatric disorders on Parkinson's disease: A nationwide follow-up study from Sweden

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Impact of psychiatric disorders on Parkinson's disease : A nationwide follow-up study from Sweden. / Li, Xinjun; Sundquist, Jan; Hwang, Helen; Sundquist, Kristina.

In: Journal of Neurology, Vol. 255, No. 1, 01.2008, p. 31-6.

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TY - JOUR

T1 - Impact of psychiatric disorders on Parkinson's disease

T2 - A nationwide follow-up study from Sweden

AU - Li, Xinjun

AU - Sundquist, Jan

AU - Hwang, Helen

AU - Sundquist, Kristina

PY - 2008/1

Y1 - 2008/1

N2 - OBJECTIVES: To analyze whether hospitalization for a psychiatric disorder predicts Parkinson's disease (PD) in men and women in different age groups after accounting for socioeconomic status and geographical region.METHODS: Data from the MigMed database were used to identify all people in Sweden hospitalized for psychiatric disorder and PD during the study period (1987 to 2001). Standardized incidence ratios (SIRs) with 95% confidence intervals (CI) for PD were calculated among those with and without hospitalization for psychiatric disorder.RESULTS: There were 1876 cases of PD among those with psychiatric disorder during the study period. The risk of developing PD was strongest among those under age 50; the SIR was 11.56 (95% CI 9.15-14.41). The risk was attenuated with increasing age in both men and women. There were similar risk patterns in all subtypes of psychiatric disorders in PD patients. The overall risk of PD among people with psychiatric disorders was higher for women than men.CONCLUSIONS: A psychiatric disorder is an appreciable risk factor for the development of PD, particularly in people under age 50. The association between PD and psychiatric disorders should be taken into account by clinicians and health care providers.

AB - OBJECTIVES: To analyze whether hospitalization for a psychiatric disorder predicts Parkinson's disease (PD) in men and women in different age groups after accounting for socioeconomic status and geographical region.METHODS: Data from the MigMed database were used to identify all people in Sweden hospitalized for psychiatric disorder and PD during the study period (1987 to 2001). Standardized incidence ratios (SIRs) with 95% confidence intervals (CI) for PD were calculated among those with and without hospitalization for psychiatric disorder.RESULTS: There were 1876 cases of PD among those with psychiatric disorder during the study period. The risk of developing PD was strongest among those under age 50; the SIR was 11.56 (95% CI 9.15-14.41). The risk was attenuated with increasing age in both men and women. There were similar risk patterns in all subtypes of psychiatric disorders in PD patients. The overall risk of PD among people with psychiatric disorders was higher for women than men.CONCLUSIONS: A psychiatric disorder is an appreciable risk factor for the development of PD, particularly in people under age 50. The association between PD and psychiatric disorders should be taken into account by clinicians and health care providers.

KW - Adult

KW - Age Distribution

KW - Age of Onset

KW - Aged

KW - Aged, 80 and over

KW - Brain/metabolism

KW - Comorbidity

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Mental Disorders/epidemiology

KW - Middle Aged

KW - Parkinson Disease/epidemiology

KW - Psychology

KW - Risk Factors

KW - Serotonin/metabolism

KW - Sex Distribution

KW - Sweden/epidemiology

U2 - 10.1007/s00415-007-0655-z

DO - 10.1007/s00415-007-0655-z

M3 - Article

VL - 255

SP - 31

EP - 36

JO - Zeitschrift fur Neurologie

JF - Zeitschrift fur Neurologie

SN - 1432-1459

IS - 1

ER -