In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone

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In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone. / van der Valk, Eline S.; van der Voorn, Bibian; Iyer, Anand M.; van den Berg, Sjoerd A.A.; Savas, Mesut; de Rijke, Yolanda B.; van den Akker, Erica L.T.; Melander, Olle; van Rossum, Elisabeth F.C.

In: European Journal of Endocrinology, Vol. 183, No. 6, 2020, p. 669-676.

Research output: Contribution to journalArticle

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van der Valk, ES, van der Voorn, B, Iyer, AM, van den Berg, SAA, Savas, M, de Rijke, YB, van den Akker, ELT, Melander, O & van Rossum, EFC 2020, 'In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone', European Journal of Endocrinology, vol. 183, no. 6, pp. 669-676. https://doi.org/10.1530/EJE-20-0077

APA

van der Valk, E. S., van der Voorn, B., Iyer, A. M., van den Berg, S. A. A., Savas, M., de Rijke, Y. B., van den Akker, E. L. T., Melander, O., & van Rossum, E. F. C. (2020). In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone. European Journal of Endocrinology, 183(6), 669-676. https://doi.org/10.1530/EJE-20-0077

CBE

van der Valk ES, van der Voorn B, Iyer AM, van den Berg SAA, Savas M, de Rijke YB, van den Akker ELT, Melander O, van Rossum EFC. 2020. In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone. European Journal of Endocrinology. 183(6):669-676. https://doi.org/10.1530/EJE-20-0077

MLA

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Author

van der Valk, Eline S. ; van der Voorn, Bibian ; Iyer, Anand M. ; van den Berg, Sjoerd A.A. ; Savas, Mesut ; de Rijke, Yolanda B. ; van den Akker, Erica L.T. ; Melander, Olle ; van Rossum, Elisabeth F.C. / In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone. In: European Journal of Endocrinology. 2020 ; Vol. 183, No. 6. pp. 669-676.

RIS

TY - JOUR

T1 - In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone

AU - van der Valk, Eline S.

AU - van der Voorn, Bibian

AU - Iyer, Anand M.

AU - van den Berg, Sjoerd A.A.

AU - Savas, Mesut

AU - de Rijke, Yolanda B.

AU - van den Akker, Erica L.T.

AU - Melander, Olle

AU - van Rossum, Elisabeth F.C.

PY - 2020

Y1 - 2020

N2 - Context: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the hypothalamic-pituitary adrenal axis (HPA axis), we hypothesize that AVP contributes to chronic hypercortisolism in obesity. Objective: To investigate whether copeptin levels are associated with Higher HairF and HairE levels in obesity. Design: A cross-sectional study in 51 adults with obesity (BMI ≥30 kg/m2). Methods: Associations and interactions between copeptin, HairF, HairE, and cardiometabolic parameters were cross-sectionally analyzed. Results: Copeptin was strongly associated with BMI and waist circumference (WC) (rho = 0.364 and 0.530, P = 0.008 and <0.001, respectively), also after correction for confounders. There were no associations between copeptin and HairF or HairE on a continuous or dichotomized scale, despite correction for confounders. Conclusion: In patients with obesity, AVP seems not a major contributor to the frequently observed high cortisol levels. Other factors which stimulate the HPA axis or affect cortisol synthesis or breakdown may be more important than the influence of AVP on long-term glucocorticoid levels in obesity.

AB - Context: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the hypothalamic-pituitary adrenal axis (HPA axis), we hypothesize that AVP contributes to chronic hypercortisolism in obesity. Objective: To investigate whether copeptin levels are associated with Higher HairF and HairE levels in obesity. Design: A cross-sectional study in 51 adults with obesity (BMI ≥30 kg/m2). Methods: Associations and interactions between copeptin, HairF, HairE, and cardiometabolic parameters were cross-sectionally analyzed. Results: Copeptin was strongly associated with BMI and waist circumference (WC) (rho = 0.364 and 0.530, P = 0.008 and <0.001, respectively), also after correction for confounders. There were no associations between copeptin and HairF or HairE on a continuous or dichotomized scale, despite correction for confounders. Conclusion: In patients with obesity, AVP seems not a major contributor to the frequently observed high cortisol levels. Other factors which stimulate the HPA axis or affect cortisol synthesis or breakdown may be more important than the influence of AVP on long-term glucocorticoid levels in obesity.

U2 - 10.1530/EJE-20-0077

DO - 10.1530/EJE-20-0077

M3 - Article

C2 - 33112256

AN - SCOPUS:85095461622

VL - 183

SP - 669

EP - 676

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 1479-683X

IS - 6

ER -