In Vitro Activity of Lipopeptides Pal-Lys-Lys-NH2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-positive Cocci.

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The in vitro activities of the lipopeptides pahnitoyl (Pal)-Lys-Lys-NH2 and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.


  • Wojciech Kamysz
  • Carmela Silvestri
  • Oscar Cirioni
  • Andrea Giacometti
  • Alberto Licci
  • Agnese Della Vittoria
  • Marcin Okroj
  • Giorgio Scalise
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medicinal Chemistry
Original languageEnglish
Pages (from-to)354-358
JournalAntimicrobial Agents and Chemotherapy
Issue number1
Publication statusPublished - 2007
Publication categoryResearch