In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

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In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia. / Lonnerholm, Gudmar; Thorn, Ingrid; Sundstrom, Christer; Frost, Britt-Marie; Abrahamsson, Jonas; Behrendtz, Mikael; Heldrup, Jesper; Jacobsson, Stefan; Li, AiHong; Olofsson, Tor; Porwit, Anna; Soderhall, Stefan; Larsson, Rolf; Forestier, Erik.

In: Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis, Vol. 33, No. 1, 2009, p. 46-53.

Research output: Contribution to journalArticle

Harvard

Lonnerholm, G, Thorn, I, Sundstrom, C, Frost, B-M, Abrahamsson, J, Behrendtz, M, Heldrup, J, Jacobsson, S, Li, A, Olofsson, T, Porwit, A, Soderhall, S, Larsson, R & Forestier, E 2009, 'In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia', Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis, vol. 33, no. 1, pp. 46-53. https://doi.org/10.1016/j.leukres.2008.06.012

APA

CBE

Lonnerholm G, Thorn I, Sundstrom C, Frost B-M, Abrahamsson J, Behrendtz M, Heldrup J, Jacobsson S, Li A, Olofsson T, Porwit A, Soderhall S, Larsson R, Forestier E. 2009. In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia. Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis. 33(1):46-53. https://doi.org/10.1016/j.leukres.2008.06.012

MLA

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Author

Lonnerholm, Gudmar ; Thorn, Ingrid ; Sundstrom, Christer ; Frost, Britt-Marie ; Abrahamsson, Jonas ; Behrendtz, Mikael ; Heldrup, Jesper ; Jacobsson, Stefan ; Li, AiHong ; Olofsson, Tor ; Porwit, Anna ; Soderhall, Stefan ; Larsson, Rolf ; Forestier, Erik. / In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia. In: Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis. 2009 ; Vol. 33, No. 1. pp. 46-53.

RIS

TY - JOUR

T1 - In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

AU - Lonnerholm, Gudmar

AU - Thorn, Ingrid

AU - Sundstrom, Christer

AU - Frost, Britt-Marie

AU - Abrahamsson, Jonas

AU - Behrendtz, Mikael

AU - Heldrup, Jesper

AU - Jacobsson, Stefan

AU - Li, AiHong

AU - Olofsson, Tor

AU - Porwit, Anna

AU - Soderhall, Stefan

AU - Larsson, Rolf

AU - Forestier, Erik

PY - 2009

Y1 - 2009

N2 - Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p < 0.001) and doxorubicin (p = 0.01 7), drugs administered during induction therapy. In patients with t(12;21) (n = 20), in vitro sensitivity to doxorubicin was an independent factor for MRD <0.1% (p = 0.031; R-2 = 0.66). Thus, data show that in vitro drug sensitivity at diagnosis is correlated to cell kill during induction therapy as measured by MRD day 29. (C) 2008 Elsevier Ltd. All rights reserved.

AB - Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p < 0.001) and doxorubicin (p = 0.01 7), drugs administered during induction therapy. In patients with t(12;21) (n = 20), in vitro sensitivity to doxorubicin was an independent factor for MRD <0.1% (p = 0.031; R-2 = 0.66). Thus, data show that in vitro drug sensitivity at diagnosis is correlated to cell kill during induction therapy as measured by MRD day 29. (C) 2008 Elsevier Ltd. All rights reserved.

KW - Doxorubicin

KW - Prednisolone

KW - 21)

KW - t(12

KW - MRD

KW - In vitro drug resistance

KW - Acute lymphoblastic leukemia

KW - Childhood

U2 - 10.1016/j.leukres.2008.06.012

DO - 10.1016/j.leukres.2008.06.012

M3 - Article

VL - 33

SP - 46

EP - 53

JO - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

T2 - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

JF - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

SN - 1873-5835

IS - 1

ER -