Increase in hepatic lipase activity after testosterone substitution in men with hypogonadism of pituitary origin

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Abstract

Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (+/- SEM) testosterone level increased from 1.8 +/- 0.5 to 16.3 +/- 2.4 nmol/l. The mean activity of HL rose from 327.1 +/- 35.2 to 432.8 +/- 57.2 mU/ml (p less than 0.02), while the activity of LPL did not change significantly, 71.0 +/- 9.1 mU/ml before and 62.2 +/- 3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of HL in men, thereby contributing to the sex difference previously recorded for HL activity.

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Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
  • Other Clinical Medicine
  • Medicinal Chemistry
Original languageEnglish
Pages (from-to)363-366
JournalActa Medica Scandinavica
Volume221
Issue number4
Publication statusPublished - 1987
Publication categoryResearch
Peer-reviewedYes