Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

Research output: Contribution to journalArticle

Abstract

Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy
Original languageEnglish
Article number52
JournalJournal of Translational Medicine
Volume14
Issue number1
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes

Related research output

Irma Mahmutovic Persson, 2016, Lund: Lund University, Faculty of Medicine. 122 p.

Research output: ThesisDoctoral Thesis (compilation)

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