Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease

Research output: Contribution to journalArticle

Abstract

Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer's disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measured CSF levels of different α-syn species in a cohort of AD patients (n = 225) who showed a CSF profile typical of AD at baseline as well as in cognitively intact controls (n = 68). CSF total α-syn (t-α-syn) significantly increased in the AD group (p < 0.0001) compared to controls, while oligomeric- and phosphorylated-Ser129-α-syn did not change significantly. ROC analysis showed a sensitivity of 85% and a specificity of 84% (AUC = 0.88) in distinguishing AD from controls. T-α-syn levels correlated positively with tau species in AD group and negatively with baseline MMSE score. Our data support the added value of measurement of CSF α-syn species for further characterization of the CSF AD profile.

Details

Authors
  • Nour K Majbour
  • Davide Chiasserini
  • Nishant N. Vaikath
  • Paolo Eusebi
  • Takahiko Tokuda
  • Wilma D J van de Berg
  • Lucilla Parnetti
  • Paolo Calabresi
  • Omar M A El-Agnaf
Organisations
External organisations
  • VU University Medical Center
  • University of Perugia
  • Kyoto Prefectural University of Medicine
  • Hamad Bin Khalifa University
  • IRCCS Fondazione Santa Lucia
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
  • Neurosciences
Original languageEnglish
Article number40263
JournalScientific Reports
Volume7
Publication statusPublished - 2017 Jan 10
Publication categoryResearch
Peer-reviewedYes