Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone

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Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone. / Fosmark, Dag S.; Berg, Jens P.; Jensen, Aase-Brith; Sandvik, Leiv; Agardh, Elisabet; Agardh, Carl-David; Hanssen, Kristian F.

In: Acta Ophthalmologica, Vol. 87, No. 5, 2009, p. 498-500.

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Fosmark, Dag S. ; Berg, Jens P. ; Jensen, Aase-Brith ; Sandvik, Leiv ; Agardh, Elisabet ; Agardh, Carl-David ; Hanssen, Kristian F. / Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone. In: Acta Ophthalmologica. 2009 ; Vol. 87, No. 5. pp. 498-500.

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TY - JOUR

T1 - Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone

AU - Fosmark, Dag S.

AU - Berg, Jens P.

AU - Jensen, Aase-Brith

AU - Sandvik, Leiv

AU - Agardh, Elisabet

AU - Agardh, Carl-David

AU - Hanssen, Kristian F.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Ophthalmology (013242810)

PY - 2009

Y1 - 2009

N2 - Purpose: We aimed to investigate associations between serum levels of the advanced glycation endproduct methylglyoxal-derived hydroimidazolone (MG-H1) and retinopathy in a sample of patients with type 1 diabetes. Methods: We conducted a cross-sectional study in a Scandinavian ophthalmology outpatient clinic on 61 randomly selected patients with type 1 diabetes. Blood samples and retinal photographs were taken at the same visit. Serum levels of hydroimidazolone immunoreactivity were determined using an immunoassay, and levels of retinopathy were determined from seven standard field stereo photographs of each eye according to the ETDRS method. Results were compared between patients with and without retinopathy. Results: Hydroimidazolone quartiles were significantly associated with retinopathy (p = 0.013). The most profound increase in occurrence of retinopathy was observed from the lowest to the second-lowest hydroimidazolone quartile. Adjusted for duration of diabetes using logistic regression, a significant difference in the presence of retinopathy was found when comparing the lowest quartile with the rest (p = 0.022). Conclusions: In our patients with type 1 diabetes, serum levels of hydroimidazolone were found to be associated with retinopathy. This is in keeping with findings in a larger sample of patients with type 2 diabetes.

AB - Purpose: We aimed to investigate associations between serum levels of the advanced glycation endproduct methylglyoxal-derived hydroimidazolone (MG-H1) and retinopathy in a sample of patients with type 1 diabetes. Methods: We conducted a cross-sectional study in a Scandinavian ophthalmology outpatient clinic on 61 randomly selected patients with type 1 diabetes. Blood samples and retinal photographs were taken at the same visit. Serum levels of hydroimidazolone immunoreactivity were determined using an immunoassay, and levels of retinopathy were determined from seven standard field stereo photographs of each eye according to the ETDRS method. Results were compared between patients with and without retinopathy. Results: Hydroimidazolone quartiles were significantly associated with retinopathy (p = 0.013). The most profound increase in occurrence of retinopathy was observed from the lowest to the second-lowest hydroimidazolone quartile. Adjusted for duration of diabetes using logistic regression, a significant difference in the presence of retinopathy was found when comparing the lowest quartile with the rest (p = 0.022). Conclusions: In our patients with type 1 diabetes, serum levels of hydroimidazolone were found to be associated with retinopathy. This is in keeping with findings in a larger sample of patients with type 2 diabetes.

KW - MG-H1

KW - (MG)

KW - methylglyoxal

KW - advanced glycation endproducts (AGEs)

KW - hydroimidazolone

KW - retinopathy

KW - type 1 diabetes

U2 - 10.1111/j.1755-3768.2008.01300.x

DO - 10.1111/j.1755-3768.2008.01300.x

M3 - Article

C2 - 18631328

VL - 87

SP - 498

EP - 500

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-3768

IS - 5

ER -