Increased sporulation rate of epidemic clostridium difficile type 027/NAP1

Research output: Contribution to journalArticle


Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread.


  • Thomas Åkerlund
  • Ingela Persson
  • Magnus Unemo
  • Torbjörn Noren
  • Bo Svenungsson
  • Marlene Wullt
  • Lars G Burman
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area
Original languageEnglish
Pages (from-to)1530-1533
JournalJournal of Clinical Microbiology
Issue number4
Publication statusPublished - 2008
Publication categoryResearch