Increased thirst and drinking in Huntington's disease and the R6/2 mouse

Research output: Contribution to journalArticle

Abstract

While Huntington's disease (HD) is a condition that primarily involves the basal ganglia, there is evidence to suggest that the hypothalamus is also affected. Because the osmoreceptors regulating thirst are situated in the circumventricular region of the hypothalamus, we were interested in whether altered thirst is a part of the HD phenotype. We used the LABORAS behavioural monitoring system and water consumption to show that drinking behaviour was abnormal in R6/2 mice. By 10 weeks of age, R6/2 mice spent significantly more time drinking and drank a greater volume than their wild-type (WT) littermates. The numbers of immunoreactive vasopressin neurons in the paraventricular nucleus (PVN) of the hypothalamus in R6/2 mice were significantly decreased from 8 weeks of age, suggesting that the change in drinking behaviour may be the result of hypothalamic dysfunction. We gave a xerostomia (dry mouth) questionnaire to HD patients and control subjects, and also measured their urine osmolality and serum vasopressin. The mean total xerostomia score was significantly higher in HD patients than in controls, indicating greater thirst in HD patients. Urine osmolality was unaffected in HD patients up to clinical stage 111, and none of the patients had diabetes. However, serum vasopressin was increased, suggesting a dysregulation in the control of hypothalamic vasopressin release. A dry mouth can affect taste, mastication and swallowing, all of which may contribute to the significant weight loss seen in both HD patients and R6/2 mice, as can dehydration. We suggest that increased thirst may be an important and clinically relevant biomarker for the study of disease progression in HD.

Details

Authors
  • Nigel I. Wood
  • Anna O. G. Goodman
  • Jorien m van der Burg
  • Veronique Gazeau
  • Patrik Brundin
  • Maria Björkqvist
  • Asa Petersen
  • Sarah J. Tabrizi
  • Roger A. Barker
  • A. Jennifer Morton
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • hypothalamus, vasopressin, xerostomia, drinking
Original languageEnglish
Pages (from-to)70-79
JournalBrain Research Bulletin
Volume76
Issue number1-2
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Translational Neuroendocrinology (013210010), Neuronal Survival (013212041)

Related research output

van der Burg, J. M., 2008, Institutionen för Experimentell Medicinsk Vetenskap, Lunds Universitet. 139 p.

Research output: ThesisDoctoral Thesis (compilation)

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