Infection with Hepatitis B and C Viruses and Risk of Lymphoid Malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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Abstract

Background: Case-control studies suggested a moderate, but consistent, association of hepatitis C virus (HCV) infection with lymphoid tissue malignancies, especially non-Hodgkin lymphoma (NHL). More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. However, prospective studies on the topic are few. Methods: A nested case-control study was conducted in eight countries participating in the EPIC prospective study. Seven hundred thirty-nine incident cases of NHL, 238 multiple myeloma (MM), and 46 Hodgkin lymphoma (HL) were matched with 2,028 controls. Seropositivity to anti-HCV, anti-HBc, and HBsAg was evaluated and conditional logistic regression was used to estimate odds ratios (OR) and corresponding 95% confidence intervals (CI) for NHL, MM, or HL, and their combination. Results: Anti-HCV seropositivity among controls in different countries ranged from 0% to 5.3%; HBsAg from 0% to 2.7%; and anti-HBc from 1.9% to 45.9%. Similar nonsignificant associations were found with seropositivity to HBsAg forNHL (OR = 1.78; 95% CI: 0.78-4.04), MM(OR = 4.00; 95% CI: 1.00-16.0), and HL(OR = 2.00; 95% CI: 0.13-32.0). The association between HBsAg and the combination of NHL, MM, and HL(OR = 2.21; 95% CI: 1.124.33) was similar for cancer diagnosed less than 3 and 3 or more years after blood collection. No significant association was found between anti-HCV and NHL, MM, or HL risk, but the corresponding CIs were very broad. Conclusions: Chronic HBV infection may increase the risk of lymphoid malignancies among healthy European volunteers. Impact: Treatment directed at control of HBV infection should be evaluated in HBsAg-seropositive patients with lymphoid tissue malignancies. Cancer Epidemiol Biomarkers Prev; 20(1); 208-14. (C) 2011 AACR.

Details

Authors
  • Silvia Franceschi
  • Mauro Lise
  • Christian Trepo
  • Pascale Berthillon
  • Shu-Chun Chuang
  • Alexandra Nieters
  • Ruth C. Travis
  • Roel Vermeulen
  • Kim Overvad
  • Anne Tjonneland
  • Anja Olsen
  • Manuela M. Bergmann
  • Heiner Boeing
  • Rudolf Kaaks
  • Nikolaus Becker
  • Antonia Trichopoulou
  • Pagona Lagiou
  • Christina Bamia
  • Domenico Palli
  • Sabina Sieri
  • Salvatore Panico
  • Rosario Tumino
  • Carlotta Sacerdote
  • Bas Bueno-de-Mesquita
  • Petra H. M. Peeters
  • Laudina Rodriguez
  • Leila Lujan Barroso
  • Miren Dorronsoro
  • Maria-Jose Sanchez
  • Carmen Navarro
  • Aurelio Barricarte
  • Beatrice Melin
  • Goran Hallmans
  • Kay-Tee Khaw
  • Nick Wareham
  • Sabina Rinaldi
  • Pierre Hainaut
  • Elio Riboli
  • Paolo Vineis
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)208-214
JournalCancer Epidemiology Biomarkers & Prevention
Volume20
Issue number1
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes