Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

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Abstract

Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.

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Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology
  • Cancer and Oncology
Original languageEnglish
Pages (from-to)791-797
JournalUrologic Oncology
Volume32
Issue number6
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes