Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

Research output: Contribution to journalArticle

Standard

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

AU - Sjödahl, Gottfrid

AU - Lövgren, Kristina

AU - Lauss, Martin

AU - Chebil, Gunilla

AU - Hultman Patschan, Oliver

AU - Gudjonsson, Sigurdur

AU - Månsson, Wiking

AU - Fernö, Mårten

AU - Leandersson, Karin

AU - Lindgren, David

AU - Liedberg, Fredrik

AU - Höglund, Mattias

PY - 2014

Y1 - 2014

N2 - Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.

AB - Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.

U2 - 10.1016/j.urolonc.2014.02.007

DO - 10.1016/j.urolonc.2014.02.007

M3 - Article

VL - 32

SP - 791

EP - 797

JO - Urologic Oncology

T2 - Urologic Oncology

JF - Urologic Oncology

SN - 1873-2496

IS - 6

ER -