Inflammation and cholesterol

Research output: Contribution to journalArticle

Abstract

Atherosclerosis develops as a result of a chronic arterial inflammation and intimal Fibrosis. The disease represents in many respects a vascular repair process activated in response to injury caused by toxic breakdown products of aggregated and oxidized lipoproteins. The initial response of the artery involves expression of adhesion molecules and recruitment of leukocytes. Degenerated lipoproteins are removed front the extracellular space by macrophages. If lipoproteins continue to I process becomes chronic and accumulate. the inflammatory cytokines stimulate smooth muscle to migrate into the intima. These cells proliferate and form an atherosclerotic plaque. Plaque cell death and inflammation in response to oxidized lipids and other toxic factors May Cause plaques to rupture.

Details

Authors
  • Jan Nilsson
  • Mikko Ares
  • Marie Lindholm
  • Gunilla Nordin Fredrikson
  • Stefan Jovinge
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • lipoproteins, atherosclerosis, macrophages, immunity, smooth muscle, cells
Original languageEnglish
Pages (from-to)A18-A25
JournalEuropean Heart Journal Supplements
Volume4
Issue numberSuppl A
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes