Inflammation-associated graft loss in renal transplant recipients

Research output: Contribution to journalArticle

Abstract

Background. Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss. Methods. We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients. Results. Baseline values were hsCRP 3.8 +/- 6.7 mg/L and IL-6 2.9 +/- 1.9 pg/mL. Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death. Conclusion. The inflammation markers hsCRP and IL-6 are associated with long-term graft outcomes in renal transplant recipients.

Details

Authors
  • Dag Olav Dahle
  • Geir Mjoen
  • Björn Öqvist
  • Hubert Scharnagl
  • Gisela Weihrauch
  • Tanja Grammer
  • Winfried Maerz
  • Sadollah Abedini
  • Gudrun E. Norby
  • Ingar Holme
  • Bengt Fellstrom
  • Alan Jardine
  • Hallvard Holdaas
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology

Keywords

  • ALERT, high-sensitivity CRP, inflammation, interleukin-6, renal, allograft survival
Original languageEnglish
Pages (from-to)3756-3761
JournalNephrology Dialysis Transplantation
Volume26
Issue number11
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes

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