Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma.

Research output: Contribution to journalArticle

Abstract

Rhinovirus infection or dsRNA stimulation increased thymic stromal lymphopoietin (TSLP), an upstream pro-allergic cytokine, in asthmatic bronchial epithelial cells. We hypothesized that dsRNA challenges superimposed on established experimental allergic asthma constitute a useful exacerbation model. We further hypothesized that TSLP is induced at dsRNA- and rhinoviral infection-induced exacerbations.

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Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy
Original languageEnglish
Pages (from-to)348-358
JournalAllergy
Volume69
Issue number3
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

Related research output

Irma Mahmutovic Persson, 2016, Lund: Lund University, Faculty of Medicine. 122 p.

Research output: ThesisDoctoral Thesis (compilation)

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