Inhibition of Fast Axonal Transport by erythro‐9‐[3‐(2‐Hydroxynonyl)]Adenine

Research output: Contribution to journalArticle

Abstract

Abstract: erythro‐9‐[3‐(2‐Hydroxynonyl)]adenine, an inhibitor of protein carboxylmethylation and dynein‐ATPase activity, inhibited fast axonal transport in vitro in frog sciatic nerves. Its site of action might be associated with an ATPase on which transport depends, since specific carboxylmethylation inhibitors lacked effects on transport. The levels of high energy phosphates and protein synthesis were unaffected by the drug at a transport‐inhibiting concentration, making disturbances due to metabolic effects less likely. An erythro‐9‐[3‐(2‐hy‐droxynonyl)]adenine‐sensitive ATPase was looked for in various nerve fractions but has so far not been resolved.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell Biology

Keywords

  • ATP‐ases, Axonal transport, EHNA
Original languageEnglish
Pages (from-to)1342-1345
Number of pages4
JournalJournal of Neurochemistry
Volume43
Issue number5
Publication statusPublished - 1984
Publication categoryResearch
Peer-reviewedYes