Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.

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Abstract

Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.

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Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
  • Clinical Medicine
  • Endocrinology and Diabetes
Original languageEnglish
Article numbere65020
JournalPLoS ONE
Volume8
Issue number6
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes

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