Initial tests with a new cardiac assist device

Research output: Contribution to journalArticle

Abstract

Before, during, and after cardiac intervention, there is occasionally a need for circulatory support because of hemodynamic deterioration. For this purpose, a new minimally invasive cardiac assist device has been developed, and an early prototype has been studied in a bench test and in three pigs. The pump is a catheter system with a distal motor driven propeller (0-15,000 rpm) surrounded by a cage. The catheter was first tested in a tube in a water bath, where efficiency with respect to pressure generation and flow properties was measured. In the pig experiments, the pump was placed in the descending part of the aorta via a graft, and hemodynamic effects were recorded with three different propellers. The bench tests showed a velocity dependent pressure generation in the tube to the second power of the rpm, and 30 cm of water (> 22 mm Hg) could easily be achieved with all propellers. A pressure dependent flow in the tube was observed, with maximum flows of 20 L at 12,000 rpm and 27 L at 15,000 rpm. In the animal experiments, there was a velocity dependent mean pressure difference across the propeller, with up to 48 mm of mercury for the biggest propeller. An increase in cardiac output in all of the pigs was observed as well as a drop in pressure in the proximal part of the aorta. This study demonstrates the efficiency of this new device in vitro and in vivo. Hemodynamic changes are pronounced and are related to the speed and size of the propeller.

Details

Authors
  • Öyvind Reitan
  • Hans Öhlin
  • B Peterzen
  • H Granfeldt
  • Stig Steen
  • H Emanuelsson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
  • Surgery

Keywords

  • Cardiocirculatory support, Device, Bench test, Non invasive method, Prototype, Animal, Pig, Artiodactyla, Ungulata, Mammalia, Vertebrata, Intensive cardiocirculatory care
Original languageEnglish
Pages (from-to)317-321
JournalASAIO Journal
Volume45
Issue number4
Publication statusPublished - 1999
Publication categoryResearch
Peer-reviewedYes