Insulin release and pancreatic insulin is reduced in young prediabetic BB rats

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Insulin release and pancreatic insulin is reduced in young prediabetic BB rats. / Svenningsen, A.; Dyrberg, T.; Markholst, H.; Binder, C.; Lernmark, A.

In: Acta Endocrinologica, Vol. 112, No. 3, 24.09.1986, p. 367-371.

Research output: Contribution to journalArticle

Harvard

Svenningsen, A, Dyrberg, T, Markholst, H, Binder, C & Lernmark, A 1986, 'Insulin release and pancreatic insulin is reduced in young prediabetic BB rats', Acta Endocrinologica, vol. 112, no. 3, pp. 367-371.

APA

Svenningsen, A., Dyrberg, T., Markholst, H., Binder, C., & Lernmark, A. (1986). Insulin release and pancreatic insulin is reduced in young prediabetic BB rats. Acta Endocrinologica, 112(3), 367-371.

CBE

Svenningsen A, Dyrberg T, Markholst H, Binder C, Lernmark A. 1986. Insulin release and pancreatic insulin is reduced in young prediabetic BB rats. Acta Endocrinologica. 112(3):367-371.

MLA

Vancouver

Svenningsen A, Dyrberg T, Markholst H, Binder C, Lernmark A. Insulin release and pancreatic insulin is reduced in young prediabetic BB rats. Acta Endocrinologica. 1986 Sep 24;112(3):367-371.

Author

Svenningsen, A. ; Dyrberg, T. ; Markholst, H. ; Binder, C. ; Lernmark, A. / Insulin release and pancreatic insulin is reduced in young prediabetic BB rats. In: Acta Endocrinologica. 1986 ; Vol. 112, No. 3. pp. 367-371.

RIS

TY - JOUR

T1 - Insulin release and pancreatic insulin is reduced in young prediabetic BB rats

AU - Svenningsen, A.

AU - Dyrberg, T.

AU - Markholst, H.

AU - Binder, C.

AU - Lernmark, A.

PY - 1986/9/24

Y1 - 1986/9/24

N2 - The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P < 0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P < 0.01). The extractable pancreatic insulin was 30% (P < 0.05) less in the BB/H rats. Total insulin release expressed relative to the pancreatic insulin content, was therefore not different between the two groups. It is concluded that about 20-40 days before the mean age of clinical onset of IDDM in BB/H rats, the capacity to release insulin in response to D-glucose is reduced along with a diminished pancreatic insulin content. This abnormality seems to be preceded only by islet cell surface antibodies but not by insulitis.

AB - The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P < 0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P < 0.01). The extractable pancreatic insulin was 30% (P < 0.05) less in the BB/H rats. Total insulin release expressed relative to the pancreatic insulin content, was therefore not different between the two groups. It is concluded that about 20-40 days before the mean age of clinical onset of IDDM in BB/H rats, the capacity to release insulin in response to D-glucose is reduced along with a diminished pancreatic insulin content. This abnormality seems to be preceded only by islet cell surface antibodies but not by insulitis.

UR - http://www.scopus.com/inward/record.url?scp=0022541591&partnerID=8YFLogxK

M3 - Article

C2 - 3529783

AN - SCOPUS:0022541591

VL - 112

SP - 367

EP - 371

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 1479-683X

IS - 3

ER -