Insulin Sensitivity and Carotid Intima-Media Thickness Relationship Between Insulin Sensitivity and Cardiovascular Risk Study

Research output: Contribution to journalArticle

Abstract

Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results-We studied a European cohort of 525 men and 655 women (mean age, 44 +/- 8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intimamedia thickness in the common carotid artery (CCA-IMT) was significantly higher (P< 0.05) in the lowest M/I tertile, whereas in women CCA-IMT was higher (P< 0.0005) in the highest fasting plasma glucose tertile (after adjustment for established risk factors). In multiple regression models, with CCA-IMT as the dependent variable and with risk factors and univariate metabolic correlates as independent variables, circulating free fatty acids and the leptin: adiponectin ratio replaced M/ I as independent metabolic determinants of CCA-IMT in men. The strongest metabolic determinant of CCA-IMT in women was fasting plasma glucose. Three-year CCA-IMT changes were not associated with any cardiometabolic risk factor. Conclusions-In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose.

Details

Authors
  • Michaela Kozakova
  • Andrea Natali
  • Jacqueline Dekker
  • Henning Beck-Nielsen
  • Markku Laakso
  • Peter Nilsson
  • Beverley Balkau
  • Ele Ferrannini
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • adipokine., atherosclerosis, carotid intima, media thickness, fatty, acids, glucose
Original languageEnglish
Pages (from-to)1409-1417
JournalArteriosclerosis, Thrombosis and Vascular Biology
Volume33
Issue number6
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes