Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women

Research output: Contribution to journalArticle


OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.

DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by radio immunoassay.

RESULTS: In a multivariate model including birth weight, current weight and age, IGF-1 was significantly inversely associated with birth weight in both cycle phases, while current weight was positively associated with IGF-1 in both cycle phases although only significantly so in the follicular phase. IGF-1 concentrations in both cycle phases showed a non-significant decrease with age.

CONCLUSION: In this group of 19-25-year-old healthy nulliparous women IGF-1 displayed a significant inverse association with birth weight in both cycle phases given that the current weight was adjusted for, while current weight was positively related to IGF-1 concentrations.


External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology


  • Adult, Birth Weight, Body Weight, Female, Follicular Phase, Humans, Insulin-Like Growth Factor I, Luteal Phase, Multivariate Analysis
Original languageEnglish
Pages (from-to)11-8
Number of pages8
JournalInternational Journal of Gynecology & Obstetrics
Issue number1
Publication statusPublished - 1998 Jul
Publication categoryResearch
Externally publishedYes