Intensive treatment and stem cell transplantation in chronic myelogenous leukemia: Long-term follow-up

Research output: Contribution to journalArticle

Abstract

In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia patients aged below 56 years, not eligible for allogeneic SCT. Patients who had an HLA-identical sibling donor and no contraindication went for an allogeneic SCT (related donor, RD). After diagnosis, patients not allotransplanted received HU and IFN to keep WBC and platelet counts low. After 6 months patients with Ph-positive cells still present in the bone marrow received 1-3 courses of intensive chemotherapy. Those who became Ph-negative after IFN+HU or after 1-3 chemotherapy courses underwent autologous SCT. Some patients with poor cytogenetic response were allotransplanted with an unrelated donor (URD). IFN+HU reduced the percentage of Ph-positive metaphases in 56% of patients, and 1 patient became Ph-negative. After one or two intensive cytotherapies 86 and 88% had a Ph reduction, and 34 and 40% became Ph-negative, respectively. In patients receiving a third intensive chemotherapy 92% achieved a Ph reduction and 8% became Ph-negative. The median survival after auto-SCT (n=46) was 7.5 years. The chance of remaining Ph-negative for up to 10 years after autologous SCT was around 20%. The overall survival for allo-SCT RD (n=91) and URD (n=28) was almost the same, i.e.≈ 60% at 10 years. The median survival for all 251 patients registered was 8 years (historical controls 3.5 years). The role of the treatment schedule presented in the imatinib era is discussed. Copyright (C) 2005 S. Karger AG, Basel.

Details

Authors
  • B Simonsson
  • G Oberg
  • M Bjoreman
  • M Bjorkholm
  • J Carneskog
  • K Karlsson
  • G Gahrton
  • G Grimfors
  • R Hast
  • H Karle
  • O Linder
  • P Ljungman
  • JL Nielsen
  • J Nilsson
  • E Lofvenberg
  • C Malm
  • K Olsson
  • U Olsson-Stromberg
  • C Paul
  • L Stenke
  • J Stentoft
  • AM Uden
  • A Wahlin
  • L Vilen
  • O Weis-Bjerrum
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • chronic myelogenous leukemia, chemotherapy, intensive, interferon, stem, cell transplantation, autologous and allogeneic
Original languageEnglish
Pages (from-to)155-162
JournalActa Haematologica
Volume113
Issue number3
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)