Interaction between amphiphilic peptides and phospholipid membranes

Research output: Contribution to journalReview article

Abstract

This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane interactions are addressed including effects of peptide length charge hydrophobicity secondary structure and topology Effects of membrane composition are also illustrated including effects of membrane charge nature of the polar headgroup and presence of cholesterol and other sterols Throughout novel insights on the importance of peptide adsorption density on membrane stability are emphasized as is the correlation between peptide adsorption peptide induced leakage in model liposome systems peptide-induced lysis of bacteria and bacteria killing (C) 2010 Elsevier Ltd All rights reserved

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Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physical Chemistry

Keywords

  • Liposome, Bacteria, AMP, Antimicrobial peptide, Membrane
Original languageEnglish
Pages (from-to)467-478
JournalCurrent Opinion in Colloid & Interface Science
Volume15
Issue number6
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes

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